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FLASH GENE

Symbol

SEMA5B

contributors: mct/npt - updated : 02-02-2015

HGNC name	sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
HGNC id	10737

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	3q21.1      Physical location : 122.628.042 - 122.746.576
Synonym name	semaphorin 5B
Synonym symbol(s)	SEMG, SEMAG, KIAA1445, FLJ10372

DNA

TYPE	virus associated
STRUCTURE	119.41 kb     23 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001031702 23 - 4737 NP_001026872 - 1151 - 2009 19463192 NM_001256348 22 - 4523 NP_001243277 - 1057 - 2009 19463192 NM_001256346 23 - 4933 NP_001243275 - 1151 - 2009 19463192 NM_001256347 23 - 4579 NP_001243276 - 1205 - 2009 19463192

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       moderately Digestive liver       lowly Nervous brain hindbrain cerebellum   lowly   spinal cord         Reproductive female system ovary     moderately   male system testis     moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Muscular striatum skeletal     Nervous central

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	liver, brain, eyes

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	plexin repeat domain
	SEMA domain
	semaphorin domain
	thrombospondin type 1 repeat domain

HOMOLOGY

interspecies

homolog to murine Sema5b

Homologene

FAMILY

semaphorin family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in axonal guidance during neural development (Adams 1996)
	may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004)
	induces calpain-mediated cleavage of calcineurin (To 2007)
	regulates the development and maintenance of synapse size and number in hippocampal neurons
	SEMA5A, SEMA5B control selective retinal lamination and function
	is proteolytically processed from its transmembrane form and can function as a soluble growth cone collapsing guidance cue
	contributes potentially to a repulsive barrier for centrally projecting primary sensory axons, forcing them to turn and establish the dorsal funiculus

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

nervous system

text	regulator of axonal guidance

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	SEMA5A and SEMA5B inhibit retinal neurite outgrowth through PlexinA1 and PlexinA3 receptors
	SEMA5B acts as a FOXP1- dependent suppressor of endothelial cell proliferation, migration and sprouting, mediating the effects of FOXP1
	inhibits the growth of NGF-dependent sensory axons and this effect is mediated in part through the cell adhesion molecule CNTN2

cell & other

REGULATION

Other

proteolytic cleavage of SEMA5B results in the release of a potentially diffusible semaphorin domain that is a necessary component for its biological function in the regulation of synapse morphology (O'Connor 2009)

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS