Selected-GenAtlas references | SOURCE | GeneCards | NCBI Gene | Swiss-Prot | Orphanet | Ensembl |
HGNC | UniGene | Nucleotide | OMIM | UCSC |
Home Page |
FLASH GENE |
Symbol | SEMA5A | contributors: mct/npt - updated : 22-01-2014 |
HGNC name | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A |
HGNC id | 10736 |
|
Corresponding disease |
| ||
Location | 5p15.31 Physical location : 9.035.137 - 9.546.233 | ||
Synonym name | |||
| |||
| |||
| |||
Synonym symbol(s) | SEMAF, semF, FLJ12815, THBSR |
DNA |
TYPE | functioning gene |
STRUCTURE | 511.10 kb 23 Exon(s) |
10 Kb 5' upstream gene genomic sequence study |
---|
MAPPING | cloned | Y | linked | N | status | confirmed |
regionally located | located in the cri-du-chat critical region |
RNA |
TRANSCRIPTS | type | messenger |
---|
|
EXPRESSION |
Type | widely |
expressed in | (based on citations) | ||||||||||||||||||||||||||||||
organ(s) |
|
tissue |
|
cell lineage
cell lines
| fluid/secretion
| |
at STAGE |
physiological period | fetal |
Text | eyes, optic nerve |
PROTEIN |
PHYSICAL PROPERTIES
STRUCTURE
| |
motifs/domains
| |
| |
|
conjugated | GlycoP |
HOMOLOGY |
interspecies | homolog to rattus Sema5a (93.2 pc) |
homolog to murine Sema5a (93.7 pc) |
Homologene |
FAMILY |
CATEGORY | adhesion , signaling growth factor |
SUBCELLULAR LOCALIZATION | plasma membrane |
text | single-pass type I membrane protein |
CELLULAR PROCESS | cell life, differentiation |
PHYSIOLOGICAL PROCESS | development |
text |
PATHWAY |
metabolism |
signaling |
cell-cell signaling |
a component |
INTERACTION |
DNA |
RNA |
small molecule |
cell & other |
REGULATION |
ASSOCIATED DISORDERS |
corresponding disease(s) | CDCS |
Other morbid association(s) |
|
Susceptibility | to Parkinson disease (PD) |
Variant & Polymorphism other | AC haplotype was associated with a significant increased risk of PD and the AT haplotype showed an associated decreased risk of PD |
ANIMAL & CELL MODELS |