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FLASH GENE
Symbol SEMA4C contributors: mct/npt - updated : 21-09-2009
HGNC name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C
HGNC id 10731
Location 2q11.2      Physical location : 97.525.473 - 97.535.735
Synonym name M-Sema F
Synonym symbol(s) SEMAF, SEMAI, SEMACL1, KIAA1739, M-SEMA-F, FLJ20369, MGC126382, MGC126383
DNA
TYPE functioning gene
STRUCTURE 10.26 kb     15 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC389006 2 similar to KIAA1641 protein LOC389007 2 similar to hypothetical protein LOC150763 2q11.2 hypothetical protein LOC150763 ADRA2B 2p13-q13 adrenergic, alpha-2B-, receptor LOC200515 2q11.2 similar to hypothetical protein 7420700F21 DUSP2 2q11 dual specificity phosphatase 2 STARD7 2q11.1 START domain containing 7 FLJ20507 2q11.2 hypothetical protein FLJ20507 CIAO1 2q11.2 hypothetical protein FLJ20507 U5-200KD 2q11.1 hypothetical protein FLJ20507 KIAA1754L 2q11.2 KIAA1754-like BRRN1 2q11.2 barren homolog (Drosophila) LOC93082 2q11.2 hypothetical protein BC012317 MRF-1 FLJ10081 2p12-p11.2 hypothetical protein FLJ10081 LOC391408 2 similar to myoferlin isoform b; fer-1-like 3 LOC90342 2q11.2 similar to fer-1 like protein 3 LMAN2L 2q11.1 lectin, mannose-binding 2-like CNNM4 2p12-p11.2 cyclin M4 LOC130643 2q11.2 hypothetical LOC130643 CNNM3 2p12-p11.2 cyclin M3 DARP MGC41816 2q11.2 hypothetical protein MGC41816 SEMA4C 2q11.1 sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C LOC51252 2q11.2 hypothetical protein LOC51252 LOC391409 2 hypothetical gene supported by NM_138800 LOC375247 2q11.2 hypothetical LOC375247 DKFZp434N062 2q11.2 hypothetical protein DKFZp434N062 UNQ2430 2q11.2 ankyrin-related KIAA1641 2q11.2 KIAA1641 protein UBE3AP1 2q11.1 ubiquitin protein ligase E3A pseudogene 1 LOC389008 2 similar to KIAA1641 protein LOC151320 2q11.2 similar to autoantigen NOR-90 COX5B 2cen-q13 cytochrome c oxidase subunit Vb ACTR1B 2q11.1-q11.2 ARP1 actin-related protein 1 homolog B, centractin beta (yeast) RNU4P2 2q11.2 RNA, U4 small nuclear pseudogene 2 (U4/14) LOC130639 2q11.2 hypothetical LOC130639 ZAP70 2q12 zeta-chain (TCR) associated protein kinase 70kDa RW1 2q11.2 RW1 protein
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
15 - 3585 - 833 - Inagaki (2001)
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Nervousbrainbasal nucleistriatum highly
 brainmidbrain  highly
 nervecranial nerve  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text downregulated during induction of neural stem/progenitor cells differentiation (Wu 2009)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 1 Ig-like C2-type (immunoglobulin-like) domain
  • a PSI domain
  • a SEMA domain
  • a cytoplasmic domain containing a proline-rich region that may interact with some signaling proteins
  • HOMOLOGY
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may play a role in axon guidance
  • may function in the cortical neurons as a bi-directional transmembrane ligand through interacting with DLG4
  • may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004)
  • transmembrane semaphorin proteins which regulate axonal guidance in the developing nervous system (Wu 2007)
  • promotes terminal myogenic differentiation in a MAPK14-dependent manner (Wu 2007)
  • plays an important role in terminal myogenic differentiation, and during neurogenesis (Wu 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with GIPC PDZ domain
  • interacting with DLG3, DLG4, in the brain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS