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FLASH GENE
Symbol SEMA4B contributors: mct - updated : 06-03-2007
HGNC name sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
HGNC id 10730
Location 15q25      Physical location : 90.728.151 - 90.772.890
Synonym name
  • semaphorin 4B
  • Synonym symbol(s) SEMC, SEMAC, KIAA1745
    DNA
    TYPE functioning gene
    STRUCTURE 44.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 3843 - 837 - White
  • 15 exons
  • a 43 aa signal peptide (4.8 kda)
  • a 793 aa mature peptide (88 kda)
  • - splicing 3809 - 837 - Ota
  • 14 exons
  • a 43 aa signal peptide (4.8 kda)
  • a 793 aa mature peptide (88 kda)
  • EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveesophagus   moderately
     liver    
     mouth   predominantly
     pancreas exocrine   highly
     pharynx   moderately
    Lymphoid/Immunelymph node   moderately
     spleen    
    Nervousbrainbasal nuclei  highly
     braindiencephalonhypothalamus highly
    Reproductivefemale systemovary  moderately
     male systemprostate  moderately
    Respiratoryrespiratory tractlarynx  highly
     respiratory tracttrachea  highly
    Urinarykidney   moderately
    Visualeyeanterior segment   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a sema domain
  • a PSI domain
  • an immunoglobulin-like C2-type domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to chimpanzee SEMA4B (98 pc)
    homolog to rattus Sema4b (86.5 pc)
    homolog to murine Sema4b (84.1 pc)
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY signaling growth factor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • type I membrane protein
  • basic FUNCTION
  • inhibiting axonal extension by providing local signals to specify territories inaccessible for growing axons
  • CELLULAR PROCESS cell life, differentiation
    PHYSIOLOGICAL PROCESS development
    text
  • nervous system development
  • PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with DCBLD2 (regulation of DCBLD2 protein by ubiquitination and proteasome degradation enhanced in the presence of SEMA4B)(Nagai 2007)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS