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FLASH GENE
Symbol SEMA3C contributors: mct/npt - updated : 30-10-2017
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
HGNC id 10725
Location 7q21.11      Physical location : 80.371.854 - 80.548.667
Synonym name
  • semaphorin 3C
  • semaphorin E
  • Synonym symbol(s) SEMAK, SEMAE, SemE
    DNA
    TYPE functioning gene
    STRUCTURE 179.84 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC392063 7 similar to Farnesyl pyrophosphate synthetase (FPP synthetase) (FPS) (Farnesyl diphosphate synthetase) LOC370523 7q11.23 similar to deltex 2 LOC389526 7 hypothetical gene supported by AK024602 LOC389527 7 similar to PMS4 homolog mismatch repair protein - human LOC202802 7q11.23 similar to Williams Beuren syndrome chromosome region 19 FGL2 7q11.2 fibrinogen-like 2 LOC54103 7q21.11 hypothetical protein LOC54103 LOC392064 7 similar to hypothetical protein LOC392065 7 similar to beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase; Glucosaminyl (N-acetyl) transferase 1, core 2; beta-1,6-N-acetylglucosaminyltransferase PTPN12 7q11.23 protein tyrosine phosphatase, non-receptor type 12 LOC389528 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 AIP1 7q11.2 putative homeodomain transcription factor 2 LOC389529 7 LOC389529 LOC392066 7 similar to 60S ribosomal protein L10 (QM protein homolog) GNAI1 7q21.3-q22.1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 LOC346562 CD36 7q11.2 CD36 antigen (collagen type I receptor, thrombospondin receptor) SEMA3C 7q21-q31 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C HGF 7q21.1 hepatocyte growth factor (hepatopoietin A; scatter factor) CACNA2D1 7q21.3-q22.1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 PCLO 7q11.23-q21.3 piccolo (presynaptic cytomatrix protein) LOC389530 7 similar to [Segment 1 of 2] Piccolo protein (Aczonin) SEMA3E 7q21.11-q31.33 sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3E SEMA3A 2q37-qter sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 5189 - 751 - 2017 28315433
    18 - 4781 - 769 - 2017 28315433
    19 - 5278 - 693 - 2017 28315433
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveintestinelarge intestinecolon highly
     intestinesmall intestine  highly
    Reproductivefemale systembreastmammary gland highly
     female systemovary  highly
     male systemtestis  highly
     male systemprostate  highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarybladder   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, fetal
    Text in the developing nervous system
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal peptide
  • the SEMA domain containing about 14 cysteine residues with a RGD domain
  • an Ig-like motif
  • a psi domain
  • a C terminal short basic domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text secreted
    basic FUNCTION
  • may be involved in diverse cell survival mechanisms
  • repellent of the nerve growth cone guidance
  • may help to establish the dopaminergic projection from the midbrain to the striatum during embryonic development (Hernández-Montiel 2008)
  • had an attractive effect and enhanced axon growth (Hernández-Montiel 2008)
  • neurovascular guiding molecule, regulated directly by GATA6 (Kodo 2009)
  • promoting the migration of breast cancer cells after activation by ADAMTS1 (Esselens 2010)
  • is essential for setting stereotyped motor tract positioning in limb-derived chemotropic semaphorins
  • SEMA3C constitutes an adipocyte-derived paracrine signal that influences extracellular matrix (ECM) composition and may play a pathophysiological role in white adipose tissue (WAT)
  • SEMA3A, -3C, and -3F, likely with coreceptors NRP1, NRP2, and plexin-A1 and/or -A3, promote migration and possibly other activities of human DCs during innate and adaptive immune responses
  • promotes epithelial-to-mesenchymal transition (EMT) and stem-like phenotypes in prostate cells
  • SEMA3C promotes migration, invasion and cell dissemination
  • SEMA3C is a secreted semaphorin that plays an important role in the maintenance of cancer stem-like cells, promotes migration and invasion, and may facilitate angiogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    SEMA32C/SEMA3D signaling is an evolutionarily conserved regulator of enteric nervous system (ENS) development whose dys-regulation is a cause of enteric aganglionosis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with GATA6 (SEMA3C and PLXNA2 are directly regulated by GATA6 through consensus binding sites on their enhancer elements and GATA6 mutations disturbs semaphorin-plexin signaling to varying degrees, resulting in abnormal development of the cardiac outflow tract)(Kodo 2009)
  • ligand of receptor plexin A2 (PLXNA2)(Kodo 2009)
  • motoneuronal SEMA3C regulates the shared SEMA3 neuropilin receptors NRP1 and NRP2 levels in opposite ways at the growth cone surface
  • axonal guidance cue SEMA3C promotes normal alveolar growth
  • neural crest-derived SEMA3C activates endothelial NRP1 for cardiac outflow tract septation
  • FOXA1 is a negative regulator of SEMA3C and SEMA3C is a novel target of AR, GATA2, and FOXA1
  • SEMA3C drives activation of multiple RTKs including EGFR, ERBB2, and MET in a cognate ligand-independent manner via PLXNB1
  • cell & other
    REGULATION
    activated by cleavage by ADAMTS1, and thus contributing to the metastatic program (Esselens 2010)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in the synovial tissue of rheumatoid arthritis and osteoarthritis
    tumoral     --other  
    aberrant expression of SEMA3C is correlated with poor prognosis of pancreatic ductal adenocarcinoma (PDAC) patients and promotes tumor growth and metastasis by activating ERK1/2 signaling pathway
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS