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FLASH GENE
Symbol SEMA3B contributors: mct/npt - updated : 16-11-2016
HGNC name sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
HGNC id 10724
Location 3p21.31      Physical location : 50.305.039 - 50.314.570
Synonym name
  • semaphorin A
  • semaphorin V
  • semaphorin 3B
  • Synonym symbol(s) LUCA-1, SEMAA, SEMA5, SemA, semaV, FLJ34863
    DNA
    TYPE functioning gene
    STRUCTURE 9.53 kb     19 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    18 - 2986 - 748 - Koyama (2008)
    18 - 2989 - 749 - Koyama (2008)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach    
    Endocrineadrenal gland   highly
    Nervousbrain    
     nervecranial nerve  highly
    Reproductivefemale systemovary   
     female systemplacenta  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal signal peptide
  • the SEMA domain containing about 14 cysteine residues
  • an Ig-like motif
  • a C terminal short basic domain
  • HOMOLOGY
    Homologene
    FAMILY
  • semaphorin family
  • CATEGORY secretory , tumor suppressor
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • repellent of the nerve growth cone guidance
  • inhibiting axonal extension by providing local signals to specify territories inaccessible for growing axons
  • may be involved in regulating cell-sorting in the formation and regeneration of the periodontal attachment structure (Lallier 2004)
  • can act as a tumor suppressor by inducing apoptosis either by reexpression in tumor cells or applied as a soluble ligand (Castro-rivera 2004)
  • angiogenesis inhibitor that is inactivated by furin-like pro-protein convertases (Varshavsky 2008)
  • role of the PLXNA2 receptor in SEMA3A and SEMA3B signal transduction
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • member of class 3 semaphorins (Koyama 2008)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with VEGF(compete with SEMA3B for binding on the cell surface and antagonizing the negative regulatory effect of SEMA3B on cell growth)
  • interacting with IGFBP6 (IGFBP6 is the effector of tumor suppressor activity of SEMA3B)(Koyama 2008)
  • interacting with VEGFA (VEGFA, produced by tumor cells, acts as an autocrine survival factor and SEMA3B mediates its tumor-suppressing effects, at least in part, by blocking this VEGF autocrine activity)(Castro-Rivera 2004)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   LOH    
    in breast and non-small cell lung cancer
    tumoral       loss of function
    by hypermethylation in non-small cell lung cancer
    tumoral     --low  
    by hypermethylation in hepatocellular carcinomas and cholangiocarcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS