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FLASH GENE
Symbol SELP contributors: mct - updated : 03-01-2013
HGNC name selectin P (granule membrane protein 140kDa, antigen CD62)
HGNC id 10721
Location 1q24.2      Physical location : 169.558.089 - 169.599.377
Synonym name granulocyte membrane protein
Synonym symbol(s) CD62P, GRMP, GMP140, PADGEM, CD62, PSEL, LECAM3
DNA
TYPE functioning gene
STRUCTURE 41.29 kb     17 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status confirmed
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
17 - 3185 - 830 - -
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvesselscapillary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Epithelialbarrier/liningendothelium  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N terminal C-type lectin domain
  • an EGF-like motif, six short consensus repeats
  • sushi structure with nine conserved cysteines per repeat
  • a short cytoplasmic tail
  • isoforms Precursor
    HOMOLOGY
    Homologene
    FAMILY selectin/LECAM family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text platelet alpha-granule membrane redistributing to plasma membrane during platelet activation and degranulation
    basic FUNCTION
  • mediating interaction of leukocytes with blood vessel wall
  • adhesion molecule involved in the pathogenesis of inflammation, thrombosis, and oncogenesis
  • role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes
  • endothelial-derived P-selectin is just as important as platelet-derived P-selectin in promoting lung metastasis and also plays an important role in liver metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • CD63 is an essential cofactor to SELP
  • protein
  • sorting nexin 17
  • CD162(P-selectin glycoprotein ligad 1)or SELPLG
  • interactions between SELP and the SELPLG mediate the earliest adhesive events during an inflammatory response
  • cell & other leukocytes
    REGULATION
    induced by thrombin,histamine,peroxides from platelet alpha granule
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased leucocyte adhesion
    constitutional     --over  
    in PXE patients potentially due to oxidative stress and elevated protease activity in pseudoxanthoma elasticum
    Susceptibility
  • to thromboembolic strocke
  • drepanocytosis with reduced gravity (increasing HBF level)
  • to recurrent spontaneous abortions
  • to Systemic lupus erythematosus
  • Variant & Polymorphism SNP
  • S290N and N562D increased the risk of myocardial infarction
  • V640L is predictor of thromboembolic strocke
  • SNP associated with paucisymptomatic drepanocyosis
  • rs6127 showed a significant association with recurrent spontaneous abortions
  • polymorphism in the upstream region may reduce expression of SELP, promoting Systemic lupus erythematosus
  • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancermetastases 
    attractive therapeutic target for preventing metastasis in multiple organs
    ANIMAL & CELL MODELS
  • CD63-deficient mice exhibit a significant reduction in both leukocyte rolling and recruitment
  • transgenic mice constitutively expressed human P-selectin in platelets, endothelial cells, and macrophages