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FLASH GENE
Symbol SELL contributors: mct - updated : 19-10-2016
HGNC name selectin L (lymphocyte adhesion molecule 1)
HGNC id 10720
Location 1q24.2      Physical location : 169.659.805 - 169.680.843
Synonym name
  • lymph node homing receptor
  • Leu-8 antigen short form
  • lymphocyte adhesion molecule 1
  • Synonym symbol(s) CD62L, LYAM1, TQ1, LAM1, LNHR, LSEL, Leu-8, PLNHR, LECAM1
    DNA
    TYPE functioning gene
    STRUCTURE 21.05 kb     9 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    9 - 2442 - 385 - 2011 21316337
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymph node   moderately
     spleen   moderately
     thymus   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticgranulocyte
    Blood/Hematopoieticmonocyte
    Blood/HematopoieticNK cell
    Blood/Hematopoieticthymocyte
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a N terminal C-type lectin domain
  • an EGF-like motif
  • six short consensus repeats
  • two sushi (CCP/SCR) structure with two conserved cysteines per repeat
  • a short cytoplasmic tail
  • transmembrane and cytoplasmic domains of SELL lack the propensity to self-associate in membranes
  • conjugated GlycoP
    HOMOLOGY
    interspecies ortholog to rattus Sell
    ortholog to murine Sell
    Homologene
    FAMILY family of adhesion/homing receptors
    CATEGORY adhesion , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    text
  • integral to plasma membrane
  • type I membrane protein
  • basic FUNCTION
  • mediating the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes
  • SELL-mediated NK cell recruitment plays a crucial role in the control of tumor metastasis into secondary lymphoid organs
  • role for SELL adhesion system in mediating cytotrophoblast emigration from the placenta
  • KLF2 promotes the expression of the selectin SELL which is involved in T cell trafficking
  • plays a crucial role in the first step of the adhesion cascade, enabling leukocytes to migrate into surrounding tissues during inflammation and immune surveillance (
  • protein intrinsic information of SELL leads to decoration with specific N-glycans, which in turn may be related to L-selectin function (
  • important in the transient attachment of leukocytes to endothelial cells, which plays a role in inflammation processes and is one of the earliest events in the pathogenesis of atherosclerosis
  • may play a role in the development of ischemic stroke
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule other,
  • sugar
  • protein
  • CD34
  • MCAM1
  • KLF2 directly activates the promoters of SELL and sphingosine-1-phosphate receptor 1, whose expression is critical for T cell egress from the thymus and homing to the lymph nodes
  • interacting with CD44 (TM domains of SELL and CD44 play a crucial role in cell adhesion under flow by targeting receptors to microvilli or the cell body, respectively)
  • CALM1 associates with the cytoplasmic domain of SELL to regulate ectodomain shedding of L-selectin on the other side of the plasma membrane
  • interacting with KLF2
  • LRRC32 expression appears to alter the surface expression of activation markers of T cells such as SELL
  • MUC16 is the SELE and SELL ligand expressed by metastatic pancreatic cancer cells
  • PAEP interacts with SELL to induce IL6 production in monocytes/macrophages by activating the ERK signaling pathway
  • over-activation of ADAM17 in NK cells may be detrimental to their effector functions by down-regulating surface expression of FCGR3A and SELL
  • EZR and MSN play mutually exclusive roles in modulating SELL signalling and shedding to control protrusion dynamics and polarity during monocyte transendothelial migration (TEM)
  • cell & other
    REGULATION
    Other regulated by FOXO1, that controls the expression of L-selectin, an essential homing molecule, in human T lymphocytes
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to Graves disease (GD)
    Variant & Polymorphism other
  • polymorphisms are associated with GD susceptibility
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS