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FLASH GENE
Symbol SELENBP1 contributors: mct/pgu - updated : 24-10-2012
HGNC name selenium binding protein 1
HGNC id 10719
Location 1q21.2      Physical location : 151.336.780 - 151.345.164
Synonym name selenium binding protein 56 Kd
Synonym symbol(s) SEBP, HSP56, HSBP, LPSB, FLJ13813, SP56, SBP1, SBP56
DNA
TYPE functioning gene
STRUCTURE 8.43 kb     12 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
HCP1 1q21.3 cytochrome c, somatic pseudogene SETDB1 1q21 SET domain, bifurcated 1 LASS2 1q11 LAG1 longevity assurance homolog 2 (S. cerevisiae) ANXA9 1q21 annexin A9 FLJ11280 1q21.3 hypothetical protein FLJ11280 BNIPL 1q21.2 BCL2/adenovirus E1B 19kD interacting protein like HTCD37 1q21 TcD37 homolog FLJ20519 1q21.3 hypothetical protein FLJ20519 SPEC1 1q21.2 hypothetical protein FLJ20519 AF1Q 1q21 hypothetical protein FLJ20519 MGC29891 1q21.3 hypothetical protein MGC29891 SEMA6C 1q21.2 sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C FLJ23467 1q21.3 hypothetical protein FLJ23467 LOC388695 1 similar to hypothetical protein SB145 SCNM1 1q21.3 sodium channel modifier 1 TMOD4 1q12 tropomodulin 4 (muscle) TCFL1 1q21 transcription factor-like 1 PIP5K1A 1q22-q24 phosphatidylinositol-4-phosphate 5-kinase, type I, alpha PSMD4 1q21.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 4 KIAA1441 1q21.3 KIAA1441 protein PIK4CB 1q21 phosphatidylinositol 4-kinase, catalytic, beta polypeptide RFX5 1q21 regulatory factor X, 5 (influences HLA class II expression) SELENBP1 1q21-q22 selenium binding protein 1 PSMB4 1q21 proteasome (prosome, macropain) subunit, beta type, 4 POGZ 1q21.1 pogo transposable element with ZNF domain CGN 1q21 cingulin TUFT1 1q21-q23 tuftelin 1 SNX27 1q21.3 sorting nexin family member 27 TNRC4 1q21 trinucleotide repeat containing 4 FLJ36032 1q21.3 hypothetical protein FLJ36032 MRPL9 1q21 mitochondrial ribosomal protein L9
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
11 - 1582 - 410 - 2000 10799528
12 - 1768 - 472 - 2000 10799528
12 - 1977 56 514 - 2000 10799528
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
blood / hematopoieticspleen    
Cardiovascularheart    
Digestiveintestine   highly
Endocrinethyroid    
Nervousbrain    
Respiratorylung    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsecretoryglandularendocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to Selenbp1
Homologene
FAMILY selenium-binding protein family
CATEGORY transport carrier
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,cytosolic
intracellular,nucleus,nucleolus
basic FUNCTION
  • may be involved in the initial sequential events in rapid cell outgrowth, such as determining direction of cell outgrowth and recruitment of actin monomer
  • implicated in selenium-dependent cell growth inhibition
  • may play a role in ubiquitination/deubiquitination-mediated protein degradation pathways in a selenium-dependent manner
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intra Golgi protein transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    selenium Se2-
    protein
  • interacting with USP33 in a selenium-dependent manner
  • SELENBP1 and GPX1 form a physical association (interaction between two distinct selenium-containing proteins that may enhance the understanding of the mechanisms by which selenium and selenoproteins affect carcinogenesis)
    • cell & other
    REGULATION
    activated by by selenium treatment in the normal HOSE cells
    repressed by androgen
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    cortex of schizophrenic patient and in peripheral blood cells
    tumoral     --low  
    in ovarian cancer cells
    tumoral     --low  
    in liver tissues of patients with hepatocarcinoma (HCC)
    tumoral     --low  
    down-regulation may play a key role in the tumorigenic process of gastric carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • potentially novel biomarker for prognosis of gastric cancer
    • Therapy target
    ANIMAL & CELL MODELS