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FLASH GENE
Symbol SELE contributors: mct - updated : 03-01-2013
HGNC name selectin E (endothelial adhesion molecule 1)
HGNC id 10718
Location 1q24.2      Physical location : 169.691.781 - 169.703.220
Synonym name
  • leukocyte endothelial cell adhesion molecule 2
  • Synonym symbol(s) CD62E, ELAM, ELAM1, LEM2, ESEL
    DNA
    TYPE functioning gene
    STRUCTURE 11.44 kb     14 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    GCSH 16q24 glycine cleavage system protein H (aminomethyl carrier) GPR161 1q23.3 G protein-coupled receptor 161 MGC3794 1q23.2 putative MAPK activating protein RPL34P1 1q23-q24 ribosomal protein L34 pseudogene 1 LOC375035 1q23.3 hypothetical protein LOC375035 MGC12538 1q23.3 hypothetical protein MGC12538 TBX19 1q23-q24 T-box 19 LOC391131 1 similar to glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 XCL2 1q23-q25 chemokine (C motif) ligand 2 XCL1 1q23 chemokine (C motif) ligand 1 DPT 1q12-q23 dermatopontin MGC4473 1q23.3 hypothetical protein MGC4473 LOC391132 1 similar to ribosomal protein L29 ATP1B1 1q23.2-q23.3 ATPase, Na+/K+ transporting, beta 1 polypeptide NME7 1q24 non-metastatic cells 7, protein expressed in (nucleoside-diphosphate kinase) BLZF1 1q24-q25 basic leucine zipper nuclear factor 1 (JEM-1) LOC57821 1q24 hypothetical protein LOC57821 SLC19A2 1q23.2-q23.3 solute carrier family 19 (thiamine transporter), member 2 F5 1q23.2-q23.3 coagulation factor V (proaccelerin, labile factor) SELP 1q23.2-q41.2 selectin P (granule membrane protein 140kDa, antigen CD62) SELL 1q23.2-q23.3 selectin L (lymphocyte adhesion molecule 1) SELE 1q23.2-q23.1 selectin E (endothelial adhesion molecule 1) MGC9084 1q23.3 hypothetical protein MGC9084 FLJ10706 1q23.3 hypothetical protein FLJ10706 PACE-1 1q23.3 ezrin-binding partner PACE-1 KIFAP3 1q23.2 kinesin-associated protein 3 MRPS10P1 1q23.2 mitochondrial ribosomal protein S10 pseudogene 1 LOC149281 1q23.3 similar to AD-003 protein LOC388713 1 LOC388713 FLJ11752 1q23.3 NTKL-binding protein 1 PRRX1 1q23-1q25 paired related homeobox 1 LOC391133 1 similar to hypothetical protein BC015183 FMO3 1q23-q24 flavin containing monooxygenase 3 LOC388714 1 similar to Putative dimethylaniline monooxygenase [N-oxide forming] 6 (Flavin-containing monooxygenase 6) (FMO 6) (Dimethylaniline oxidase 6) FMO2 1q23-q25 flavin containing monooxygenase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3875 - 610 - -
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
     mouth   highly
    Endocrineparathyroid   highly
    Respiratorylung    
     respiratory tracttrachea  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/lining   
    Muscularstriatumskeletal  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal C-type lectin domain
  • an EGF-like motif
  • six short consensus repeats, sushi structure
  • six conserved cysteines per repeat
  • a short cytoplasmic tail
  • HOMOLOGY
    interspecies homolog to murine Sele
    Homologene
    FAMILY Selectin/Lecam family
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton
    intracellular,nuclear envelope
    text type 1 membrane protein
    basic FUNCTION
  • participating in the interaction between leukocytes and the endothelium and may be involved in the pathogenesis of atherosclerosis
  • plays critical roles in tethering leukocytes to endothelial cells (ECs)
  • pivotal molecule for endothelial progenitor cells homing to ischemic limb and vasculogenesis
  • during inflammation, SELE-expressed on cytokine-activated endothelial cells mediates leukocyte rolling under flow
  • SELE clusters in both clathrin-coated pits and lipid rafts of endothelial cells but is internalized in clathrin-coated pits
  • expressed by cardiac fibroblasts with ICAM1 and CXC chemokines in response to proinflammatory cytokine stimulation in the infarcted myocardium
  • might be an important factor involved in the process of cerebral aneurysm formation and rupture, by promoting inflammation and weakening cerebral artery walls
  • role of endothelial cell adhesion molecules SELP, SELE and ICAM1 in leucocyte recruitment induced by exogenous methylglyoxal in diabetes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HOXA9 acts as an obligate proinflammatory factor by mediating cytokine induction of SELE
  • CD40/CD40L interaction induces SELE-dependent adhesion of leukocytes to endothelial cells and reduces endothelial cell migration
  • MUC16 is the SELE and SELL ligand expressed by metastatic pancreatic cancer cells
  • stimulus-dependent methylation of HOXA9 is essential for SELE expression during the endothelial cells inflammatory response
  • ADRB3 stimulation acts through up-regulation of SELE in adipose tissue endothelial cells to induce neutrophil infiltration
  • cell & other
    REGULATION
    induced by IL1B,TNFA
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    reduced leucocyte rolling velocity
    constitutional     --over  
    in patients with hereditary angioedema, during inter-attack periods
    Susceptibility
  • to atherosclerosis
  • to essential hypertension
  • to pancreatic cancer development
  • Variant & Polymorphism other
  • mutations of the gene may be a risk factor in atherosclerosis
  • S128R "C" allele may confer an increased susceptibility to pancreatic cancer development
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS