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FLASH GENE
Symbol SEH1L contributors: - updated : 12-09-2005
HGNC name SEH1-like (S. cerevisiae)
HGNC id 30379
Location 18p11.21      Physical location : 12.947.982 - 12.987.533
Synonym name
  • yeast (S cerevisiae) SEC13L-related
  • Synonym symbol(s) SEC13LR, Seh1, SEH1A, SEH1B, SEC13L
    DNA
    TYPE functioning gene
    STRUCTURE 39.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1891 46.6 421 - Pan (unpublished)
    - splicing 3513 - 360 - Pan (unpublished)
  • having an additonal segment in the 3' coding region as compared to variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   moderately
    Digestiveintestinesmall intestine  predominantly
     pancreas exocrine   moderately
    Lymphoid/Immunelymph node   moderately
    Reproductivemale systemtestis  highly
     male systemprostate  moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • Ser and Thr rich, containing several beta-transducin-like WD-40 repeats (six WD repeats)
  • mono polymer complex
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae SEC13L
    homolog to murine Seh1l
    Homologene
    FAMILY
  • WD-repeat SEC13 family
  • CATEGORY transport carrier channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome,kinetochore
    intracellular,nuclear envelope,pore
    text
  • nuclear pore complex
  • localized to kinetochores in mitosis
  • basic FUNCTION
  • required for vesicle biogenesis from endoplasmic reticulum
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component nuclear pore complex Nup107-160
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC24A
  • SEC24B
  • SEC24C
  • SEC24D
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS