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FLASH GENE

Symbol

SECTM1

contributors: np/ - updated : 21-03-2003

HGNC name	secreted and transmembrane 1
HGNC id	10707

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	17q25.3      Physical location : 80.278.900 - 80.291.921
Synonym name	K12 protein
	type 1a transmembrane protein
Synonym symbol(s)	K12

DNA

TYPE	functioning gene
STRUCTURE	13.02 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

regionally located

cognate and located upstream of CD7

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003004 5 - 2282 NP_002995 - 248 - 1998 9480746

EXPRESSION

Type

expressed in	(based on citations)
organ(s)

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte Homo sapiens

cell lineage
cell lines	breast cancer cell lines
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

extracellular N terminus and cleaved signal peptide, both membrane bound (12kD) and secreted isoforms (20kD) derived from the N terminal region of the gene

HOMOLOGY

interspecies

homolog to murine Sectm1

Homologene

FAMILY

CATEGORY

immunity/defense , signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
text	type 1a transmembrane protein; perinuclear Golgi-like pattern

basic FUNCTION

involved in hematopoietic and/or immune system processes

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	mesodeim development

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

Golgi associated

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS