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FLASH GENE

Symbol

SEC61G

contributors: SGE - updated : 13-04-2010

HGNC name	Sec61 gamma subunit
HGNC id	18277

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	7p11.2      Physical location : 54.819.940 - 54.826.939
Synonym name	protein transport protein Sec61 subunit gamma
	protein transport protein SEC61 gamma subunit
Synonym symbol(s)	SSS1

DNA

TYPE	functioning gene
STRUCTURE	7.00 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_001012456 4 - 480 NP_001012474 - 68 - Hartmann (1994) NM_014302 4 - 484 NP_055117 - 68 - Hartmann (1994)

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive liver       moderately Nervous brain       moderately Reproductive male system prostate     moderately Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic bone marrow       Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae SSS1p
	homolog to E.coli SecEp
	homolog to murine Sec61g (100.00pc)
	homolog to rattus Sec61g (100.00pc)

Homologene

FAMILY

SECE/SEC61-GAMMA family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	tail-anchored membrane protein

basic FUNCTION

involved in protein translocation in the endoplasmic reticulum

CELLULAR PROCESS

protein, post translation, targeting

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	protein transport

PATHWAY

metabolism

signaling

a component

heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS