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FLASH GENE

Symbol

SEC61B

contributors: mct/npt/pgu - updated : 27-03-2009

HGNC name	Sec61 beta subunit
HGNC id	16993

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	9q22.33      Physical location : 101.984.569 - 101.992.900
Synonym name	protein translocation complex beta
	protein transport protein Sec61 subunit beta

DNA

TYPE	functioning gene
STRUCTURE	8.33 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

Physical map

RNA

TRANSCRIPTS	type	messenger

text	multiple polyadenylated sites

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 4 - 583 9.8 96 - 2007 17215517

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive liver       highly   salivary gland       moderately   stomach       highly Endocrine neuroendocrine pituitary     highly   pancreas       moderately   thyroid       moderately Nervous brain       moderately   nerve       highly Reproductive male system prostate     highly Respiratory lung       moderately Urinary kidney       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine

cell lineage
cell lines
fluid/secretion	highly in lymph

at STAGE

physiological period

fetal

Text	predominantly in umbilical cord

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER)

conjugated

PhosphoP

mono polymer

heteromer , trimer

HOMOLOGY

interspecies	homolog to rattus Sec61b (99 pc)
	homolog to murine Sec61b (99 pc)
	homolog to Drosophila Sec61beta (71.6 pc)

Homologene

FAMILY

SEC61-beta family

CATEGORY

transport channel

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
text	tail-anchored membrane protein
	single-pass membrane protein
	newly synthesised SERP1 and SEC61B can accumulate in a cytosolic, soluble complex with the ATPase ASNA1 before insertion into ER-derived membranes

basic FUNCTION	involved in protein translocation in the endoplasmic reticulum
	acting as a P-P-bond-hydrolysis-driven protein transmembrane transporter
	playing a role in EGF receptor trafficking to the nucleus and gene expression
	tail-anchored (TA) protein, having a functions in the ER stress response

CELLULAR PROCESS

protein, post translation, targeting

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	protein transport

PATHWAY

metabolism

signaling

a component	heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
	part of a complex composed of SEC61, SEC62 and SEC63

INTERACTION

DNA

RNA

small molecule

protein	interacting with SEC62
	interacting with EGFR (EGFR retrotranslocated from the ER to the cytoplasm by SEC61B)
	interacting with BCAP31

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS