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FLASH GENE
Symbol SEC61B contributors: mct/npt/pgu - updated : 27-03-2009
HGNC name Sec61 beta subunit
HGNC id 16993
Location 9q22.33      Physical location : 101.984.569 - 101.992.900
Synonym name
  • protein translocation complex beta
  • protein transport protein Sec61 subunit beta
  • DNA
    TYPE functioning gene
    STRUCTURE 8.33 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC389777 9 LOC389777 LOC286359 9q22.33 hypothetical protein LOC286359 PCTAIRE2BP 9q22.33 tudor repeat associator with PCTAIRE 2 TMOD1 9q22.32-q22.33 tropomodulin 1 LOC158427 9q22.33 PP4189 NCBP1 9q34.1 nuclear cap binding protein subunit 1, 80kDa XPA 9q22.32 xeroderma pigmentosum, complementation group A LOC392371 9 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) FOXE1 9q22.3 forkhead box E1 (thyroid transcription factor 2) NAP1 19q13.33 pronapsin A HEMGN 9q22.33 hemogen ANP32B 9q22.32 acidic (leucine-rich) nuclear phosphoprotein 32 family, member B NANS 9p24.1-p23 N-acetylneuraminic acid synthase (sialic acid synthase) TRIM14 9q22.32 tripartite motif-containing 14 CORO2A 9q22.3 coronin, actin binding protein, 2A TBC1D2 9q22.33 TBC1 domain family, member 2 GPR51 9q22.1 G protein-coupled receptor 51 SAMD6 9q31.1 sterile alpha motif domain containing 6 GALNT12 9q22.33 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 12 (GalNAc-T12) LOC392372 9 similar to Nucleoside diphosphate kinase B (NDK B) (NDP kinase B) (P18) COL15A1 9q22.32-q22.33 collagen, type XV, alpha 1 TGFBR1 9q22 transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa) ALG2 9q31.1 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) SEC61B 9q22.32-q31.3 asparagine-linked glycosylation 2 homolog (yeast, alpha-1,3-mannosyltransferase) LOC347265 9q31.1 similar to bA13B9.3 (novel protein similar to KRT8) LOC389778 9 LOC389778 NR4A3 9q22.32-q22.33 nuclear receptor subfamily 4, group A, member 3 STX17 9q31.1 syntaxin 17 INVS 9q31 inversin FLJ20287 9q31.1 hypothetical protein FLJ20287 MGC17337 9q31.1 similar to RIKEN cDNA 5730528L13 gene TMEFF1 9q31 transmembrane protein with EGF-like and two follistatin-like domains 1 LOC347273 9q31.1 similar to RIKEN cDNA 2310039E09 LOC392373 9 similar to ACTB protein LOC392374 9 similar to uracil DNA glycosylase
    RNA
    TRANSCRIPTS type messenger
    text multiple polyadenylated sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 583 9.8 96 - 2007 17215517
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   moderately
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas   moderately
     thyroid   moderately
    Nervousbrain   moderately
     nerve   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period fetal
    Text predominantly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER)
  • conjugated PhosphoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Sec61b (99 pc)
    homolog to murine Sec61b (99 pc)
    homolog to Drosophila Sec61beta (71.6 pc)
    Homologene
    FAMILY
  • SEC61-beta family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • tail-anchored membrane protein
  • single-pass membrane protein
  • newly synthesised SERP1 and SEC61B can accumulate in a cytosolic, soluble complex with the ATPase ASNA1 before insertion into ER-derived membranes
  • basic FUNCTION
  • involved in protein translocation in the endoplasmic reticulum
  • acting as a P-P-bond-hydrolysis-driven protein transmembrane transporter
  • playing a role in EGF receptor trafficking to the nucleus and gene expression
  • tail-anchored (TA) protein, having a functions in the ER stress response
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • part of a complex composed of SEC61, SEC62 and SEC63
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SEC62
  • interacting with EGFR (EGFR retrotranslocated from the ER to the cytoplasm by SEC61B)
  • interacting with BCAP31
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS