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FLASH GENE
Symbol SEC61B contributors: mct/npt/pgu - updated : 27-03-2009
HGNC name Sec61 beta subunit
HGNC id 16993
Location 9q22.33      Physical location : 101.984.569 - 101.992.900
Synonym name
  • protein translocation complex beta
  • protein transport protein Sec61 subunit beta
  • DNA
    TYPE functioning gene
    STRUCTURE 8.33 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    text multiple polyadenylated sites
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 583 9.8 96 - 2007 17215517
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver   highly
     salivary gland   moderately
     stomach   highly
    Endocrineneuroendocrinepituitary  highly
     pancreas   moderately
     thyroid   moderately
    Nervousbrain   moderately
     nerve   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   moderately
    Urinarykidney   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    cell lineage
    cell lines
    fluid/secretion highly in lymph
    at STAGE
    physiological period fetal
    Text predominantly in umbilical cord
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • C-terminal transmembrane region that mediates post-translational insertion into the membrane of the endoplasmic reticulum (ER)
  • conjugated PhosphoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to rattus Sec61b (99 pc)
    homolog to murine Sec61b (99 pc)
    homolog to Drosophila Sec61beta (71.6 pc)
    Homologene
    FAMILY
  • SEC61-beta family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text
  • tail-anchored membrane protein
  • single-pass membrane protein
  • newly synthesised SERP1 and SEC61B can accumulate in a cytosolic, soluble complex with the ATPase ASNA1 before insertion into ER-derived membranes
  • basic FUNCTION
  • involved in protein translocation in the endoplasmic reticulum
  • acting as a P-P-bond-hydrolysis-driven protein transmembrane transporter
  • playing a role in EGF receptor trafficking to the nucleus and gene expression
  • tail-anchored (TA) protein, having a functions in the ER stress response
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • part of a complex composed of SEC61, SEC62 and SEC63
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with SEC62
  • interacting with EGFR (EGFR retrotranslocated from the ER to the cytoplasm by SEC61B)
  • interacting with BCAP31
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS