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FLASH GENE
Symbol SEC61A2 contributors: SGE - updated : 13-04-2010
HGNC name Sec61 alpha 2 subunit (S. cerevisiae)
HGNC id 17702
Location 10p13      Physical location : 12.171.639 - 12.211.956
Synonym name
  • likely ortholog of mouse SEC61, alpha subunit 2 (S. cerevisiae)
  • protein transport protein Sec61 subunit alpha isoform 2
  • Sec61 alpha form 2
  • Synonym symbol(s) FLJ10578
    DNA
    TYPE functioning gene
    STRUCTURE 40.32 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2129 - 437 - Hartmann (1994)
  • isoform c
  • 12 - 2528 - 476 - Hartmann (1994)
  • isoform a
  • 11 - 2462 - 454 - Hartmann (1994)
  • isoform b
  • EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Sec61a2 (100.00pc)
    homolog to yeast S.cerevisiae Sec61p
    homolog to E.coli SecYp
    homolog to rattus Sec61a2 (100.00pc)
    Homologene
    FAMILY
  • SecY/SEC61-alpha family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • playing a crucial role in the insertion of secretory and membrane polypeptides into the ER
  • required for assembly of membrane and secretory proteins
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • heterotrimer of three membrane proteins- alpha, beta and gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • tightly associated with membrane-bound ribosomes, either directly or through adapter proteins
  • REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS