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FLASH GENE
Symbol SEC61A1 contributors: npt/mct - updated : 25-08-2016
HGNC name Sec61 alpha 1 subunit (S. cerevisiae)
HGNC id 18276
Corresponding disease
HNFJ4 hyperuricemic nephropathy, familial juvenile 4
Location 3q21.3      Physical location : 127.771.211 - 127.790.525
Synonym name
  • protein transport protein SEC61 alpha subunit isoform 1
  • sec61 homolog
  • Synonym symbol(s) HSEC61, SEC61A, HNFJ4, SEC61
    DNA
    TYPE functioning gene
    STRUCTURE 19.31 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3656 52.3 476 - 2009 19933108
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   predominantly
    Cardiovascularheart   moderately
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to murine Sec61a
    homolog to yeast S.cerevisiae Sec61p
    homolog to E.coli SecYp
    homolog to C.elegans Y57G11C.15
    homolog to Drosophila Sec61alpha
    Homologene
    FAMILY
  • SECY/SEC61- alpha family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    text
  • present in finely granular structures and was located exclusively in the ER
  • basic FUNCTION
  • playing a crutial role in the insertion of secretory and membrane polypeptides into the ER
  • required for assembly of membrane and secretory proteins
  • SEC61A1 complexes that are present in the ER membrane of nucleated cells form calcium leak channels that may play a crucial role in calcium homeostasis
  • heterotrimeric SEC61A1 complex, which forms a dynamic polypeptide-conducting channel in the ER membrane
  • role for SEC61A1 in the formation of the minimal filtration unit of the kidney, the nephron
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPA5 limits ER Ca(2+) leakage through the SEC61A1 complex by binding to the ER lumenal loop 7 of Sec61A1 in the vicinity of tyrosine 344
  • DNAJB11 associates with a large complex including SEC61A1
  • co-chaperone-controlled gating of the SEC61A1 channel by HSPA5 is particularly important for cells, which are highly active in protein secretion, and breakdown of this regulatory mechanism can cause apoptosis and disease
  • PEX3 inserts co-translationally into the mammalian ER via the SEC61A1 translocon
  • cell & other
  • tightly binding to membrane-bound ribosomes, either directly or through adapter proteins
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HNFJ4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS