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FLASH GENE
Symbol SEC61A1 contributors: npt/mct - updated : 25-08-2016
HGNC name Sec61 alpha 1 subunit (S. cerevisiae)
HGNC id 18276
Corresponding disease
HNFJ4 hyperuricemic nephropathy, familial juvenile 4
Location 3q21.3      Physical location : 127.771.211 - 127.790.525
Synonym name
  • protein transport protein SEC61 alpha subunit isoform 1
  • sec61 homolog
  • Synonym symbol(s) HSEC61, SEC61A, HNFJ4, SEC61
    DNA
    TYPE functioning gene
    STRUCTURE 19.31 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FLJ20123 3q21.3 hypothetical protein FLJ20123 MGC11349 3q21.3 hypothetical protein MGC11349 FLJ31300 3q21.3 hypothetical protein FLJ31300 CHST13 3q21.3 carbohydrate (chondroitin 4) sulfotransferase 13 MGC34728 3q21.3 hypothetical protein MGC34728 TXNRD3 3p13-q13.33 thioredoxin reductase 3 LOC255330 3q21.3 hypothetical protein LOC255330 LOC391571 3 similar to Splicing factor 3A subunit 2 (Spliceosome associated protein 62) (SAP 62) (SF3a66) MGC13016 DKFZp564A176 3q21.3 hypothetical protein DKFZp564A176 LOC285311 3q21.3 hypothetical gene supported by AK097460 TPRA40 3q21.2 seven transmembrane domain orphan receptor MCM2 3q21 MCM2 minichromosome maintenance deficient 2, mitotin (S. cerevisiae) PODLX2 15 endoglycan ABTB1 3q21 ankyrin repeat and BTB (POZ) domain containing 1 MGLL 3q21.3 monoglyceride lipase LOC166348 3q21.3 similar to RIKEN cDNA 4833415F11 SEC61A1 3q21.3 similar to RIKEN cDNA 4833415F11 RUVBL1 3q21 RuvB-like 1 (E. coli) SELB 3q21.3 elongation factor for selenoprotein translation LOC389146 3 LOC389146 DNAJB8 3q21.3 DnaJ (Hsp40) homolog, subfamily B, member 8 GATA2 3q21 GATA binding protein 2 LOC391572 3 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) GR6 3q21 similar to Transmembrane protein Tmp21 precursor (21 kDa Transmembrane trafficking protein) (p24delta) (S31III125) (S31I125) (Tmp-21-I) FLJ40473 3q21.3 hypothetical protein FLJ40473 RPN1 3q21.3-q25.2 ribophorin I RAB7 3q21 RAB7, member RAS oncogene family LOC391573 3 similar to mKIAA1860 protein LOC391574 3 similar to MAP/microtubule affinity-regulating kinase 4; MAP/microtubule affinity-regulating kinase 4L; MARK4 serine/threonine protein kinase LOC389147 3 similar to WD repeat domain 10 isoform 3 LOC391575 3 similar to Fat-specific protein FSP27 homolog ACAD9 3q21.3 acyl-Coenzyme A dehydrogenase family, member 9 KIAA1257 3q21.3 KIAA1257 protein FLJ12057 3q21.3 hypothetical protein FLJ12057 GP9 3q21 glycoprotein IX (platelet) LOC339122 KIAA1160 3q21.3 KIAA1160 protein ZNF9 3p13.3-q24 zinc finger protein 9 (a cellular retroviral nucleic acid binding protein) COPG 3q21.3 coatomer protein complex, subunit gamma DC12 3q21.3 DC12 protein H1FX 3q21.3 H1 histone family, member X LOC90288 3q21.3 hypothetical protein LOC90288 MBD4 3q21-q22 methyl-CpG binding domain protein 4 WDR10 3q21 WD repeat domain 10
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3656 52.3 476 - 2009 19933108
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen   highly
     thymus   predominantly
    Cardiovascularheart   moderately
    Digestiveliver   highly
    Endocrinepancreas   highly
    Nervousbrain   highly
    Reproductivemale systemprostate  highly
    Respiratorylung   highly
    Urinarykidney   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies ortholog to murine Sec61a
    homolog to yeast S.cerevisiae Sec61p
    homolog to E.coli SecYp
    homolog to C.elegans Y57G11C.15
    homolog to Drosophila Sec61alpha
    Homologene
    FAMILY
  • SECY/SEC61- alpha family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic,granule
    text
  • present in finely granular structures and was located exclusively in the ER
  • basic FUNCTION
  • playing a crutial role in the insertion of secretory and membrane polypeptides into the ER
  • required for assembly of membrane and secretory proteins
  • SEC61A1 complexes that are present in the ER membrane of nucleated cells form calcium leak channels that may play a crucial role in calcium homeostasis
  • heterotrimeric SEC61A1 complex, which forms a dynamic polypeptide-conducting channel in the ER membrane
  • role for SEC61A1 in the formation of the minimal filtration unit of the kidney, the nephron
  • CELLULAR PROCESS protein, post translation, targeting
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text protein transport
    PATHWAY
    metabolism
    signaling
    a component
  • gamma forming a transmembrane channel (Sec61 complex) where proteins are translocated across and integrated into the ER membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HSPA5 limits ER Ca(2+) leakage through the SEC61A1 complex by binding to the ER lumenal loop 7 of Sec61A1 in the vicinity of tyrosine 344
  • DNAJB11 associates with a large complex including SEC61A1
  • co-chaperone-controlled gating of the SEC61A1 channel by HSPA5 is particularly important for cells, which are highly active in protein secretion, and breakdown of this regulatory mechanism can cause apoptosis and disease
  • PEX3 inserts co-translationally into the mammalian ER via the SEC61A1 translocon
  • cell & other
  • tightly binding to membrane-bound ribosomes, either directly or through adapter proteins
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) HNFJ4
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS