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FLASH GENE

Symbol

SEC31B

contributors: mct - updated : 16-02-2008

HGNC name	SEC31 homolog B (S. cerevisiae)
HGNC id	23197

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	10q24.32      Physical location : 102.246.402 - 102.279.595
Synonym name	secretory pathway component Sec31B-1
	SEC31-like 2 (S. cerevisiae)
Synonym symbol(s)	SEC31B-1, SEC31L2

DNA

TYPE	functioning gene
STRUCTURE	33.00 kb     26 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 1 26 - 4631 128 1179 - Strausberg, Stankewich (2006) canonical WD repeats in an N-terminal domain that binds Sec13 and a proline-rich C-terminal region that presumably binds Sec23/24 contributes to the diversity of the mammalian COPII coat variant 2 or SEC31-bt - - 4895 52 394 - Strausberg, Stankewich (2006) a frameshift resulting in e shorter isoform with a distinct C-terminus contains a preserved WD-repeat domain but lacks the C-terminal proline-rich region

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Lymphoid/Immune thymus       highly Nervous brain hindbrain cerebellum   highly Reproductive male system testis     highly Respiratory respiratory tract larynx     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a putative Ca2+/calmodulin-dependent kinase II phosphorylation site
	three WD40 repeats

HOMOLOGY

interspecies	homolog to rattus LOC361763
	ortholog to S. cerevisiae Sec31p

Homologene

FAMILY

CATEGORY

transport

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth

basic FUNCTION

unknown

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS