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FLASH GENE
Symbol SEC31A contributors: npt/ - updated : 16-05-2007
HGNC name SEC31 homolog A (S. cerevisiae)
HGNC id 17052
Location 4q21.22      Physical location : 83.739.814 - 83.812.419
Synonym name
  • yeast Sec31p homolog
  • protein-transport protein SEC31
  • SEC31-like 1 (S. cerevisiae)
  • Web1-like protein
  • yeast Sec31p homolog
  • Synonym symbol(s) ABP125, ABP130, KIAA0905, SEC31L1, HSPC275, HSPC334, DKFZp686N07171, MGC90305
    DNA
    TYPE functioning gene
    STRUCTURE 72.59 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 splicing 4241 133 1220 - Kim
    25 splicing 4124 129 1181 - Kim
  • lacking two in-frame coding exons compared to variant 1
  • 27 - 4199 - 1205 - Shibata
    26 - 3902 - 1106 - Shibata
    27 - 4244 - 1220 - Shibata
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  highly
     female systembreastmammary gland moderately
     male systemtestis  highly
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Sec31l1
    ortholog to murine Sec31l1
    homolog to yeast Sec31 protein
    Homologene
    FAMILY
  • WD repeat SEC31 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • COPII vesicle coat
  • colocalized with SEC13
  • basic FUNCTION
  • required for ER-Golgi transport
  • colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endoplasmic reticulum to golgi vesicle-mediated transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCD6
  • bound ALG2, in a Ca(2+)-dependent manner and colocalized with ALG2 at ER exit sitestarget for PDCD6 (Yamasaki 2006)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with ALK, in a translocation t(2;4)(p23;q21), in an intraabdominal inflammatory myofibroblastic tumor
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS