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FLASH GENE
Symbol SEC31A contributors: mct - updated : 29-06-2018
HGNC name SEC31 homolog A (S. cerevisiae)
HGNC id 17052
Location 4q21.22      Physical location : 83.739.814 - 83.812.419
Synonym name
  • yeast Sec31p homolog
  • protein-transport protein SEC31
  • SEC31-like 1 (S. cerevisiae)
  • Web1-like protein
  • yeast Sec31p homolog
  • Synonym symbol(s) ABP125, ABP130, KIAA0905, SEC31L1, HSPC275, HSPC334, DKFZp686N07171, MGC90305
    DNA
    TYPE functioning gene
    STRUCTURE 72.59 kb     27 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 splicing 4241 133 1220 - 2015 25540196
    25 splicing 4124 129 1181 - 2015 25540196
  • lacking two in-frame coding exons compared to variant 1
  • 27 - 4199 - 1205 - 2015 25540196
    26 - 3902 - 1106 - 2015 25540196
    27 - 4244 - 1220 - 2015 25540196
    26 - 4328 - 1200 - 2015 25540196
    24 - 3997 - 1067 - 2015 25540196
    26 - 4924 - 1166 - 2015 25540196
    27 - 4408 - 1205 - 2015 25540196
    28 - 4670 - 1220 - 2015 25540196
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularvessel   highly
    Digestiveintestinesmall intestine  moderately
    Lymphoid/Immunelymph node   highly
    Nervousbrain   moderately
    Reproductivefemale systemplacenta  highly
     female systembreastmammary gland moderately
     male systemtestis  highly
     male systemprostate  moderately
    Skin/Tegumentskin   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    Muscular    
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    interspecies ortholog to rattus Sec31l1
    ortholog to murine Sec31l1
    homolog to yeast Sec31 protein
    Homologene
    FAMILY
  • WD repeat SEC31 family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic,vesicle
    text
  • COPII vesicle coat
  • colocalized with SEC13
  • basic FUNCTION
  • required for ER-Golgi transport
  • colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text endoplasmic reticulum to golgi vesicle-mediated transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PDCD6
  • bound ALG2, in a Ca(2+)-dependent manner and colocalized with ALG2 at ER exit sitestarget for PDCD6 (Yamasaki 2006)
  • binding of PDCD6 to SEC31A and inhibition of COPII vesicle budding is furthermore dependent on an intact Ca(2+)-binding site at EF-hand 1 of PDCD6
  • PDCD6/SEC31A interactions were not required for the localization of SEC31A to ER exit sites per se but appeared to acutely regulate the stability and trafficking of the cargo receptor p24 and the distribution of the vesicle tether protein p115
  • ANXA11, physically associates with SEC31A by the adaptor function of PDCD6
  • PDCD6 binding with SEC31A
  • USP8 interacts with and deubiquitinates SEC31A; the interaction was mediated by the adaptor protein STAM
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion translocation    
    fused with ALK, in a translocation t(2;4)(p23;q21), in an intraabdominal inflammatory myofibroblastic tumor
    tumoral fusion      
    SEC31A-ALK, in lung carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • SEC31A-ALK fusion transcript in clinical NSCLC, could be a novel diagnostic and therapeutic target for patients with non-small cell lung carcinoma (NSCLC)
  • Therapy target
    ANIMAL & CELL MODELS