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FLASH GENE

Symbol

SEC31A

contributors: npt/ - updated : 16-05-2007

HGNC name	SEC31 homolog A (S. cerevisiae)
HGNC id	17052

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q21.22      Physical location : 83.739.814 - 83.812.419
Synonym name	yeast Sec31p homolog
	protein-transport protein SEC31
	SEC31-like 1 (S. cerevisiae)
	Web1-like protein
	yeast Sec31p homolog
Synonym symbol(s)	ABP125, ABP130, KIAA0905, SEC31L1, HSPC275, HSPC334, DKFZp686N07171, MGC90305

DNA

TYPE	functioning gene
STRUCTURE	72.59 kb     27 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_014933 27 splicing 4241 NP_055748 133 1220 - Kim NM_016211 25 splicing 4124 NP_057295 129 1181 - Kim lacking two in-frame coding exons compared to variant 1 NM_001077208 27 - 4199 NP_001070676 - 1205 - Shibata NM_001077206 26 - 3902 NP_001070674 - 1106 - Shibata NM_001077207 27 - 4244 NP_001070675 - 1220 - Shibata

EXPRESSION

Type	ubiquitous

constitutive of

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel       highly Digestive intestine small intestine     moderately Lymphoid/Immune lymph node       highly Nervous brain       moderately Reproductive female system placenta     highly   female system breast mammary gland   moderately   male system testis     highly   male system prostate     moderately Skin/Tegument skin       moderately Visual eye       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow       Connective bone       Muscular         Nervous peripherous

cell lineage
cell lines
fluid/secretion	blood

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to rattus Sec31l1
	ortholog to murine Sec31l1
	homolog to yeast Sec31 protein

Homologene

FAMILY

WD repeat SEC31 family

CATEGORY

structural protein

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic,vesicle
text	COPII vesicle coat
	colocalized with SEC13

basic FUNCTION	required for ER-Golgi transport
	colocalize with SEC13, one of the other components of COPII, in the subcellular structures corresponding to the vesicle transport function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

cellular trafficking transport

text	endoplasmic reticulum to golgi vesicle-mediated transport

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	PDCD6
	bound ALG2, in a Ca(2+)-dependent manner and colocalized with ALG2 at ER exit sitestarget for PDCD6 (Yamasaki 2006)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral fusion translocation     fused with ALK, in a translocation t(2;4)(p23;q21), in an intraabdominal inflammatory myofibroblastic tumor

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS