Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SEC16B contributors: mct/npt/pgu - updated : 20-08-2012
HGNC name SEC16 homolog B (S. cerevisiae)
HGNC id 30301
Location 1q25.2      Physical location : 177.898.241 - 177.939.050
Synonym name
  • regucalcin gene promotor region related protein
  • leucine zipper transcription regulator 2
  • Synonym symbol(s) KIAA1928, RGPR-p117, RGPR, LZTR2, DKFZp686C2486, FLJ23871, FLJ25761, FLJ33652, FLJ36620, SEC16S
    DNA
    TYPE functioning gene
    STRUCTURE 40.81 kb     26 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    25 - 4024 - 1060 - 2007 17192411
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver   highly
    Endocrinepancreas    
    Nervousbrainhindbrainmedulla oblongata  
     nervespinal nervesciatic highly
    Respiratoryrespiratory tracttrachea  highly
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, lens, anterior segment, retina foveal, macular RPE, choroid
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal region is necessary and sufficient for transitional ER localization
  • C-terminal region rich in Gly and Ser, and not conserved in SEC16A (this unique AA composition of the C-terminal region may allow SEC16B to localize to special ER domains, where it modulates the export of PEX16 and PEX3 from the ER)
  • HOMOLOGY
    interspecies homolog to murine Rgpr
    Homologene
    FAMILY
  • SEC16 family
  • CATEGORY transport
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the budding of transport vesicle from the endoplasmic reticulum
  • plays a role in membrane traffic from the endoplasmic reticulum
  • role in the biogenesis of mammalian peroxisomes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
  • present at multiple copies in a heteromeric complex
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • plays an important role in the transport of PEX16 from the ER to peroxisomes in mammalian cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to obesity
    Variant & Polymorphism SNP rs10913469 associated to obesity risk
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS