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FLASH GENE
Symbol SEC14L2 contributors: npt/mct - updated : 01-03-2011
HGNC name SEC14-like 2 (S. cerevisiae)
HGNC id 10699
Location 22q12.2      Physical location : 30.792.932 - 30.821.277
Synonym name
  • supernatant protein factor
  • tocopherol-associated protein
  • alpha-tocopherol-associated protein
  • squalene transfer protein
  • Synonym symbol(s) C22orf6, TAP, KIAA1658, SPF, KIAA1186, MGC65053
    DNA
    TYPE functioning gene
    STRUCTURE 28.35 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    NF2 22q12.2 neurofibromin 2 (bilateral acoustic neuroma) CABP7 22q12.2 calcium binding protein 7 LOC55954 22cen-q12.3 hypothetical protein LOC55954 HSPC051 22cen-q12.3 ubiquinol-cytochrome c reductase complex (7.2 kD) ASC1p100 22q12.1 ASC-1 complex subunit P100 MTMR3 22q12.2 myotubularin related protein 3 LOC391326 22 similar to h2-calponin MGC26710 22q12.2 hypothetical protein MGC26710 LIF 22q12.2 leukemia inhibitory factor (cholinergic differentiation factor) OSM 22q12.2 oncostatin M TBC1D10 22q12.1-qter TBC1 domain family, member 10 SF3A1 22q12.1 splicing factor 3a, subunit 1, 120kDa LOC388891 22 similar to hypothetical protein 4930562D19 LOC200312 22q12.2 similar to RIKEN cDNA 0610009J22 SEC14L2 22q12.2 SEC14-like 2 (S. cerevisiae) HSPC242 22q hypothetical protein HSPC242 LOC391327 22 similar to solute carrier family 39 (zinc transporter), member 1; zinc-iron regulated transporter-like gene; solute carrier family 39 (zinc transporter), member 3; zinc/iron regulated transporter-like SEC14L3 22q12.2 SEC14-like 3 (S. cerevisiae) LOC376844 SEC14L4 22q12.1 SEC14-like 4 (S. cerevisiae) PTPNS1L 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like CST 22q12.2 protein tyrosine phosphatase, non-receptor type substrate 1-like PES1 22q12.2 pescadillo homolog 1, containing BRCT domain (zebrafish) TCN2 22q12.2 transcobalamin II; macrocytic anemia SLC35E4 22q12.2 solute carrier family 35, member E4 LOC391328 22 similar to tum- transplantation antigen P198 DUSP18 22q12.1 dual specificity phosphatase 18 OSBP2 22q12.2 oxysterol binding protein 2 FLJ35801 22q12.2 hypothetical protein FLJ35801 ZCWCC1 22q12.2 zinc finger, CW-type with coiled-coil domain 1 FLJ20618 22q12.2 hypothetical protein FLJ20618 LOC388893 22 LOC388893 SMTN 22q12.2 smoothelin SELM 22q12.2 selenoprotein SelM PIB5PA 22q12.2 phosphatidylinositol (4,5) bisphosphate 5-phosphatase, A PLA2G3 22q11.2-q13.2 phospholipase A2, group III FLJ38628 22q12.3 hypothetical protein FLJ38628
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 4303 46 403 - 2003 12454003
    11 - 1845 44.6 392 - 2003 12454003
    - - 4054 - 320 - 2000 10829015
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine   
     liver   highly Homo sapiens
    Nervousbrain   highly
    Reproductivefemale systembreast  highly Homo sapiens
     male systemprostate  highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text tissues lowly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a CRAL/TRIO domain
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae SEC14-like 2
    homolog to rattus 45 kDa secretory protein
    ortholog to murine Sec14l2
    homolog to Drosophila CG13893
    Homologene
    FAMILY
  • hydrophobic ligand binding proteins
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    text
  • cytoplasmic in absence of alpha-tocopherol
  • nuclear in presence of alpha-tocopherol
  • basic FUNCTION
  • playing a role in an intracellular transport system
  • having a transcriptional activatory activity via its association with alpha-tocopherol
  • may modulate, in a tocopherol-sensitive manner, phosphatidylinositol-3-kinase, a central enzyme in signal transduction, cell proliferation, and apoptosis
  • regulating cholesterol biosynthesis by increasing the transfer of squalene to a metabolic active pool in the cell
  • stimulates squalene monooxygenase, a downstream enzyme in the cholesterol biosynthetic pathway)
  • may act as an intracellular shuttle for alpha-TOS (Alpha-tocopheryl succinate), promoting apoptosis initiated by this vitamin E analogue
  • may participate in intracellular lipid transport (phospholipids, squalene, tocopherol analogues and derivatives) or influence regulatory lipid-dependent events
  • may mediate lipid uptake, secretion, presentation, and sub-cellular localization in a tissue-specific manner, possibly using organelle- and enzyme-specific docking sites
  • may serve as a tumor suppressor in breast carcinogenesis
  • may participate in intracellular lipid transport and influence regulatory lipid-dependent events
  • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    cholesterol biosynthesis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
  • binding with high affinity to alpha-tocopherol (vitamin E)
  • binding with a weaker affinity to other tocopherols and to tocotrienols
  • REGULATION
    Other regulated both post-translationally through phosphorylation and at the level of expression (phosphorylation may provide a means for the rapid short term modulation of cholesterol synthesis)
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS