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FLASH GENE
Symbol SEC13 contributors: npt - updated : 09-03-2006
HGNC name SEC13 homolog (S. cerevisiae)
HGNC id 10697
Location 3p25-p24      Physical location : 10.342.616 - 10.362.858
Synonym name
  • SEC13-like 1 (S. cerevisiae)
  • SEC13-related protein
  • Synonym symbol(s) D3S1231E, SEC13R, SEC13L1, npp-20
    DNA
    TYPE functioning gene
    STRUCTURE 20.00 kb     9 Exon(s)
    MAPPING cloned Y linked N status provisional
    Map see VHL VHL
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1468 35.9 325 - Swaroop
    - - 1428 35.5 322 - Swaroop
  • lacking an alternate exon compared to variant 1
  • lacking three aa at the N-terminus compared to isoform a
  • EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • ser and thr rich
  • six beta-transducin-like WD-40 repeats
  • a C-terminal nuclear localization signal in the sixth WD repeat
  • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae SEC13-like 1
    ortholog to rattus Sec13l1
    ortholog to murine Sec13l1
    ortholog to chicken sec13l1
    Homologene
    FAMILY
  • WD repeat SEC13 family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • requiring for vesicle biogenesis from endoplasmic reticulum
  • may coupling and regulating functions between the nucleus and the cytoplasm
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SEC24A
  • SEC24B
  • SEC24C
  • SEC24D
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS