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FLASH GENE

Symbol

SDR9C7

contributors: mct/npt - updated : 04-07-2017

HGNC name	short chain dehydrogenase/reductase family 9C member 7
HGNC id	29958

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	ARCI14 congenital ichthyosis, autosomal recessive 14
Location	12q13.3      Physical location : 57.316.937 - 57.328.189
Genatlas name	orphan short-chain dehydrogenase / reductase
Synonym name	retinol dehydrogenase similar protein
Synonym symbol(s)	RDHS, FLJ16333, MGC126600, MGC126602, SDRO
EC.number	1.1.1.-

DNA

TYPE	functioning gene
STRUCTURE	11.25 kb     4 Exon(s)

regulatory sequence

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_148897 4 - 1765 NP_683695 35 313 - 2009 19703561

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive esophagus         Skin/Tegument skin       highly Homo sapiens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum corneum   Homo sapiens Epithelial barrier lining epidermis stratum granulosum   Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

HOMOLOGY

interspecies	ortholog to rattus Rdhs
	ortholog to murine Sdro
	ortholog to C. elegans dhs-16

Homologene

FAMILY

short-chain dehydrogenases/reductases (SDR) family

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,cytosolic
	intracellular,nucleus

basic FUNCTION	acting as an oxidoreductase
	catalysing the metabolism of ligands that bind with nuclear receptors
	is an enzyme to convert retinal into retinol, suggesting a potential role of vitamin A metabolism in terminal differentiation of the epidermis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

ARCI14

Susceptibility

Variant & Polymorphism

Candidate gene
Marker	might be a potential prognostic and therapeutic marker for esophageal squamous cell carcinoma (ESCC) patients
Therapy target

ANIMAL & CELL MODELS