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FLASH GENE
Symbol SDK2 contributors: mct - updated : 13-02-2008
HGNC name sidekick homolog 2 (chicken)
HGNC id 19308
Location 17q25.1      Physical location : 71.330.523 - 71.640.227
Synonym name Drosophila sidekick-like
Synonym symbol(s) FLJ10832, KIAA1514
DNA
TYPE functioning gene
STRUCTURE 100.00 kb     39 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC388417 17 LOC388417 SLC39A11 17q25.1 solute carrier family 39 (metal ion transporter), member 11 LOC390811 17 similar to DNA-directed RNA polymerases III 12.5 kDa polypeptide (RNA polymerase III C11 subunit) (HsC11p) (hRPC11) (My010 protein) SSTR2 17q24.3-q25 somatostatin receptor 2 COG1 17q25.1 component of oligomeric golgi complex 1 FLJ14775 17q25.1 hypothetical protein FLJ14775 HLC-8 17q25.1 lung cancer-related protein 8 LOC390812 17 similar to cleavage and polyadenylation specific factor 4; musculus clipper/cleavage and polyadenylation specificity factor 30 kDa subunit; cleavage and polyadenylation specific factor 4, 30kD subunit CDC42EP4 17q24-q25 CDC42 effector protein (Rho GTPase binding) 4 SDK2 17q21.31 sidekick homolog 2 (chicken) LOC388418 17 hypothetical gene supported by AL833395 FLJ40319 17q25.2 hypothetical protein FLJ40319 RPL38 17q22 ribosomal protein L38 TTYH2 17q24 Tweety homolog 2 (Drosophila) DNAI2 17q25 dynein, axonemal, intermediate polypeptide 2 FLJ37300 17q25.2 hypothetical protein FLJ37300 LOC388419 17 similar to galectin 3 binding protein; L3 antigen; Mac-2-binding protein; serum protein 90K GPR142 17q25.2 G protein-coupled receptor 142 GPRC5C 17q25 G protein-coupled receptor, family C, group 5, member C
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Lymphoid/Immunelymph node   highly
Reproductivemale systemtestis  highly
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Visualamacrine cell
Visualbipolar cell
Visualganglion cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a signal sequence
  • six immunoglobulin C2 motifs
  • 13 fibronectin type III motifs
  • a single transmembrane domain, and an approximately 200-amino acid cytoplasmic domain
  • C-terminal hexapeptide, GFSSFV, conserved in all SDKs, and PDZ-binding motif required for both its synaptic localization in photoreceptors and its ability to promote lamina-specific arborization of presynaptic and postsynaptic processes in the inner plexiform layer
  • HOMOLOGY
    interspecies homolog to rattus LOC360652
    Homologene
    FAMILY immunoglobulin superfamily
    CATEGORY adhesion
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • acting as determinant of lamina-specific synaptic connectivity
  • having a structure consistent with its participation in cell-cell interaction during eye development
  • its localization and function require its incorporation into a MAGI1-containing synaptic scaffold
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with DSCAM (direct lamina-specific synaptic connections in vertebrate retina)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS