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FLASH GENE
Symbol SDK1 contributors: mct - updated : 13-02-2008
HGNC name sidekick homolog 1, cell adhesion molecule (chicken)
HGNC id 19307
Location 7p22.2      Physical location : 3.341.079 - 4.308.629
Synonym name
  • sidekick homolog 1 (chicken)
  • sidekick 1
  • protein sidekick-1
  • Synonym symbol(s) FLJ31425
    DNA
    TYPE functioning gene
    STRUCTURE 967.55 kb     45 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC285919 7p22.3 hypothetical LOC285919 RELN 7q22 reelin GNA12 7p22-p21 guanine nucleotide binding protein (G protein) alpha 12 LOC392621 7 LOC392621 LOC392740 7 hypothetical gene supported by AF290475; BC037783 FLJ42526 7q21.11 FLJ42526 protein FLJ25037 7q11.21 hypothetical protein FLJ25037 C7orf35 7q21.11 chromosome 7 open reading frame 35 PHTF2 7q11.23-q21 putative homeodomain transcription factor 2 CARD11 7p22 caspase recruitment domain family, member 11 SDK1 7p22.3 sidekick homolog 1 (chicken) LOC392702 7 LOC392702 ZNF92 19p13.1-p12 zinc finger protein 92 (HTF12) AIP1 7q11.2 zinc finger protein 92 (HTF12) LOC389457 7 LOC389457 LOC392932 7 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author LOC392703 7 similar to hypothetical protein FLJ25037 LOC392933 7 similar to protein kinase related to Raf protein kinases; Method: conceptual translation supplied by author SDK1 7p22.3 sidekick homolog 1 (chicken) LOC392934 7 similar to metabotropic glutamate receptor 8; G protein-coupled receptor, family C, group 1, member H LOC392704 7 similar to hypothetical protein MGC16733 similar to CG12113 ORC5L 7q22 origin recognition complex, subunit 5-like (yeast) LOC392705 7 similar to RIKEN cDNA 2610034N24 LOC392706 7 LOC392706 LOC392852 7 similar to THAP domain containing 5 FLJ20311 7q36.3 hypothetical protein FLJ20311 DKFZp434F142 7q11.21 hypothetical protein DKFZp434F142 LOC393079 7 similar to 60S RIBOSOMAL PROTEIN L21 LOC392970 7 similar to lipoma HMGIC fusion partner-like 3 LOC154807 GUSB 7q22.1 glucuronidase, beta FLJ10300 7q36.3 hypothetical protein FLJ10300
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    45 - 10397 - 2213 - 2007 17307840
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Lymphoid/Immunespleen   highly
    Nervousbrainhindbrainmedulla oblongata  
    Reproductivemale systemtestis  highly
    Visualeyeuveachoroid  
     eyeretina    Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningendometrium  
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousoptic nerve
    Skin/Tegumentmelanocyte
    Visualamacrine cell
    Visualbipolar cell
    Visualcone photoreceptor Homo sapiens
    Visualganglion cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a signal sequence
  • six immunoglobulin C2 motifs
  • 13 fibronectin type III motifs
  • a single transmembrane domain
  • an approximately 200-amino acid cytoplasmic domain
  • A C-terminal hexapeptide, GFSSFV, predicted to bind PDZ domains
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to drosophila Sdk
    Homologene
    FAMILY
  • transmembrane immunoglobulin superfamily
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • mediating homophilic adhesion and direct laminar targeting of neurites
  • having a structure consistent with its participation in cell-cell interaction during eye development
  • determinants of lamina-specific synaptic connectivity
  • important mediator of cellular adhesion in HIV-infected podocytes and may contribute to podocyte clustering that is characteristic of pseudocrescent formation in HIV associated nephropathy
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DSCAM1 (direct lamina-specific synaptic connections in vertebrate retina)
  • associates with the slit diaphragm linker protein MAGI1, which is already known to interact with several critical podocyte proteins including synaptopodin, ACTNA4, NPHS1, IGSF5, and beta-catenin
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in glomeruli in HIV-associated nephropathy
    constitutional     --over  
    in podocytes is an important pathogenic factor in FSGS (Focal segmental glomerulosclerosis) and the mechanism involves disruption of the actin cytoskeleton possibly via alterations in MAGI1 function (MID: 20562105)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    mouse model of chronic FSGS that implicates the sdk-1 genetic pathway as important to the pathogenesis of glomerular sclerosis