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FLASH GENE
Symbol SDHB contributors: mct/npt - updated : 16-03-2009
HGNC name succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
HGNC id 10681
Corresponding disease
PGL4 hereditary paraganglioma 4
Location 1p36.13      Physical location : 17.345.226 - 17.380.665
Synonym name
  • complex 2 of the respiratory chain, succinate-ubiquinone oxidoreductase
  • iron-sulfur subunit of complex II
  • Synonym symbol(s) SDH, IP, SDHIP, PGL4, SDH1, FLJ92337
    EC.number 1.3.5.1, 1.3.99.1
    DNA
    TYPE functioning gene
    STRUCTURE 35.44 kb     8 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    EPHA2 1p36.1 EphA2 FLJ33962 1p36.13 hypothetical protein FLJ33962 LOC343531 1p36.13 similar to oral cancer overexpressed 2; transmembrane protein 16A (eight membrane-spanning domains) MGC10731 1p36.13 hypothetical protein MGC10731 KIAA1332 1p36.23-p36.11 KIAA1332 protein DKFZp566C0424 1p36.13 putative MAPK activating protein PM20,PM21 LOC391008 1 similar to ribosomal protein L22 FLJ10420 1p36.13 hypothetical protein FLJ10420 KIAA1922 1p36.13 KIAA1922 protein LOC391009 1 hypothetical gene supported by AB007923 FLJ20719 1p31 hypothetical protein FLJ20719 LOC388597 1 LOC388597 MGC12760 1p36.13 hypothetical protein MGC12760 LOC388598 1 similar to ring finger protein 123 MSTP2 1p36.2 macrophage stimulating, pseudogene 2 EIF1AP1 1q42.3 eukaryotic translation initiation factor 1A pseudogene 1 LOC284729 1p36.13 hypothetical protein LOC284729 MSTP7 1p36.2 macrophage stimulating, pseudogene 7 LOC391010 1 similar to KIAA0454 protein LOC388599 1 LOC388599 CROCC 1pter-p36.11 ciliary rootlet coiled-coil, rootletin MFAP2 1p36.1 microfibrillar-associated protein 2 HSA9947 1p36 putative ATPase SDHB 1p36.1-p35 succinate dehydrogenase complex, subunit B, iron sulfur (Ip) PADI2 1p35.2-p35.1 peptidyl arginine deiminase, type II PADI1 1p36.13 peptidyl arginine deiminase, type I PADI3 1p36.13 peptidyl arginine deiminase, type III PADI4 1p36.13 peptidyl arginine deiminase, type IV LOC391011 1 similar to Peptidyl arginine deiminase, egg and embryo abundant TD-60 1p36.13 RCC1-like FLJ10521 1p36.13 hypothetical protein FLJ10521 LOC81569 1p36.2-p35 actin like protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 1161 28.8 280 - Kita (1990)
    EXPRESSION
    Type ubiquitous
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveliver    
     stomach   highly
    Reproductivefemale systemuteruscervix highly
    Skin/Tegumentskin   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES globular
    STRUCTURE
    motifs/domains
    conjugated FlavoP
    mono polymer heteromer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans f42a8.2
    Homologene
    FAMILY
  • succinate dehydrogenase/fumarate reductase iron-sulfur protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,inner
    basic FUNCTION
  • succinate-ubiquinone oxidoreductase, catalyzing the seventh step of the citric acid cycle (tricarboxylic acid cycle)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism organic acid
    signaling
    a component
  • complex II of mitochondrial respiratory chain, oxidative phosphorylation, (OXPHOS)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDHA and SDHB interacted specifically with SIRT3 (SIRT3 may be an important physiological regulator of SDH activity)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PGL4
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral germinal mutation      
    in pheochromocytoma and paraganglioma
    tumoral       loss of function
    in pheochromocytoma and paraganglioma
    tumoral   LOH    
    in pheochromocytoma with high-risk of recurrence or malignancy
    tumoral germinal mutation      
    in Cowden and Cowden-like syndromes
    tumoral germinal mutation      
    in familial renal cell carcinoma, with early onset
    Susceptibility
  • pheochromocytoma, paraganglioma and early-onset renal cell carcinoma
  • Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS