Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SDE2 contributors: npt - updated : 02-12-2020
HGNC name SDE2 telomere maintenance homolog
HGNC id 26643
Location 1q42.12      Physical location : -
Synonym name
  • hypothetical protein LOC163859
  • chromosome 1 open reading frame 55
  • UPF0667 protein C1orf55
  • Synonym symbol(s) FLJ35382, RP4-671D7.1 , dJ671D7.1, C1orf55
    DNA
    TYPE functioning gene
    STRUCTURE 16.65 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3987 49.6 451 - 2019 30698750
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland   highly
    Reproductivefemale systemuteruscervix  
    Urinarybladder    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal ubiquitin-like (UBL) fold, which is cleaved at a diglycine motif via a PCNA-interacting peptide (PIP) box and deubiquitinating enzyme activity, and UBL domain plays an important role in regulating replication stress response
  • a DNA-binding SAP (SAF-A/B, Acinus and PIAS) domain (SAP domains are frequently found in proteins participating in the DNA repair process)
  • cleaved C-terminal SDE2 is required for antagonizing PCNA monoubiquitination triggered by ultraviolet (UV) damage
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY unknown/unspecified
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • possible function in the DDR or in DNA repair
  • may be involved in a confined and specific DNA repair pathway, which is often the case with distinct DNA repair factors
  • is a new factor required for counteracting replication stress
  • PCNA-associated protein, playing a key role in maintaining active replication and counteracting replication stress by regulating the replication fork protection complex (FPC)
  • essential role for SDE2 in maintaining genomic integrity by stabilizing the FPC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SDE2 is a new genome surveillance factor regulated by PCNA interaction
  • SDE2 facilitates spliceosomal association of CACTIN/Cay1, with a functional link between SDE2 and CACTIN further supported by genetic interactions and pre-mRNA splicing assays
  • conditional degradation of SDE2 by the Arg/N-End rule pathway regulates stress response at replication forks
  • SDE2 directly interacts with the FPC component TIMELESS (TIM) and enhances its stability, thereby aiding TIM localization to replication forks and the coordination of replisome progression
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS