SUBCELLULAR LOCALIZATION
| extracellular
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| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,Golgi
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| intracellular,cytoplasm,organelle,lysosome
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text
| NUDT16L1 co-localized with SDC4 cytoplasmic domain in focal contacts, and interacts with various cell adhesion adaptor proteins to control cell signaling |
basic FUNCTION
| cell surface proteoglycan that bears heparan sulfate |
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involved in cell adhesion and motility |
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important component of focal adhesions that is involved in cytoskeletal reorganization |
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with SDC3,function as coreceptors for tyrosine kinases and in cell adhesion |
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contributes to endothelial tubulogenesis through interactions with THBS1 |
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critical intrinsic regulator of inflammatory reactions by protecting against osteopontin-mediated acute hepatic injury by masking functional domains of SPP1 |
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inhibitory role in CD4 T cells |
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functions as a receptor in intracellular signaling |
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GPNMB binds to SDC4 on activated T cells and inhibits allogeneic T-cell responses |
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promotes plasma membrane retention of PIP(2) by negatively regulating PLC-dependent PIP(2) degradation |
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regulating ADAMTS5 activation and artilage breakdown in osteoarthritis |
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SDC4 and RSPO3 are essential for two Wnt/PCP-driven processes-gastrulation movements and head cartilage morphogenesis |
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regulates early neutrophil migration and pulmonary inflammation in response to lipopolysaccharide |
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is a regulator of MAPK signaling |
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SDC4 independently regulates multiple small GTPases to promote fibroblast migration during wound healing |
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can participate in the Wnt/PCP pathway, unveiling its importance during neural tube closure in mammalian embryos |
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acts as a signal transducer, and affects the growth and differentiation of a number of tissues and organs |
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SDC4 participates likely in amelogenesis, and FGF10 may modulate dental epithelial cell behaviors through the regulation of SDC4 expression |
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can act as a co-receptor of growth factors and proteins of the extracellular matrix by increasing the affinity of adhesion molecules to their specific receptors |
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plays a important role in acquisition of anoikis resistance and that the conferral of anoikis resistance may suffice to transform endothelial cells |
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involved in establishment of the lamellar structure of the annulus fibrosus of the intervertebral disc |
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is a ubiquitous heparan sulfate proteoglycan cell surface receptor that modulates cell proliferation, migration, mechanotransduction, and endocytosis |
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SDC4 shedding from vascular endothelial cells played an important role in the diabetes-related impairment of angiogenesis shedding from vascular endothelial cells |
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SDC4 antagonizes the activation of DDX58 in a CYLD-mediated deubiquitination-dependent process, thereby balancing antiviral signalling to avoid deleterious effects on host cells |
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SDC4 controls flow-induced lymphatic endothelial cells (LECs) |
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polarization via regulation of VANGL2 expression |