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FLASH GENE
Symbol SDC1 contributors: mct - updated : 23-08-2016
HGNC name syndecan 1
HGNC id 10658
Location 2p24.1      Physical location : 20.400.557 - 20.425.194
Synonym name
  • CD138 antigen
  • heparan sulfate proteoglycan fibroblast growth factor receptor
  • CD138 antigen; heparan sulfate proteoglycan fibroblast growth factor receptor
  • syndecan proteoglycan 1
  • Synonym symbol(s) CD138, SDC, SYND1
    DNA
    TYPE functioning gene
    STRUCTURE 24.64 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Physical map
    LOC343930 2p24.3 similar to pMesogenin1 KCNS3 2p23-p22.2 potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 RDH14 2p24.1 retinol dehydrogenase 14 (all-trans and 9-cis) NT5C1B 2p24.1 5'-nucleotidase, cytosolic IB LOC388927 2 LOC388927 OSR1 3p22-p21.3 oxidative-stress responsive 1 LOC130500 2p24.3 similar to Uncharacterized hematopoietic stem/progenitor cells protein MDS029 LOC130502 2p24.3 similar to CG14894-PA KIAA1336 2p24.3 KIAA1336 protein MATN3 2p24-p23 matrilin 3 LAPTM4A 2p24.3 lysosomal-associated protein transmembrane 4 alpha LOC391355 2 similar to 40S ribosomal protein S16 SDC1 2p24.1 syndecan 1 LOC151457 2p24.3 similar to GTP-binding protein PUM2 2p22-p21 pumilio homolog 2 (Drosophila) ARHB 2pter-p12 ras homolog gene family, member B LOC151451 2p24.2 hypothetical LOC151451 LOC388928 2 similar to hypothetical protein LOC91942 FLJ14249 2p24.2 HS1-binding protein 3 GDF7 2p23-p24 growth differentiation factor 7 FLJ21820 2p24.2 hypothetical protein FLJ21820 APOB 2p24-p23 apolipoprotein B (including Ag(x) antigen) LOC388929 2 similar to tudor domain containing 6 protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 3309 - 310 - 2008 18064305
    5 - 3217 - 310 - 2008 18064305
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
     liver    
     stomach   highly
    Reproductivefemale systemuteruscervix  
     male systemprostate   
    Respiratoryrespiratory tractlarynx   
    Urinarybladder   highly
     kidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
     epithelial cell
    cell lineage distinct stages of differentiation of normal lymphoid cells (pre-B)
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • cytoplasmic domain binding to RAB5A, a small GTPase that regulates intracellular trafficking and signaling events, and this interaction controls the onset of SDC1 shedding (Hayashida 2008)
  • a transmembrane domain having a regulatory function in controlling focal adhesion disassembly, which in turn controls cell migration speed
  • HOMOLOGY
    Homologene
    FAMILY syndecan proteoglycan family
    CATEGORY structural protein , protooncogene , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,lumen
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,lysosome
    intracellular,nucleus
    text
  • translocates into the nucleus and hampers tumor cell proliferation
  • basic FUNCTION
  • cell surface proteoglycan bearing both heparan sulfate and chondroitin sulfate and linking the cytoskeleton
  • to the interstitial matrix
  • involved in cell-cell adhesion, organization of cell-matrix adhesion, and regulation of growth factor signaling
  • playing an essential role in maintaining intestinal epithelial barrier function
  • physiological binding partner of TIAM1 and the PDZ domain has a function in cell-matrix adhesion and cell migration
  • regulates mesenchymal tumor cell adhesion and migration, and its different domains have differential effects
  • is a regulator of focal adhesion disassembly in migrating lung epithelial cells
  • cell surface proteoglycan that can organize co-receptors into a multimeric complex to transduce intracellular signals
  • in the germinal niche is a key regulator of the maintenance and proliferation of neural progenitor cells (NPCs) during cortical neurogenesis
  • promotes vascular smooth muscle cells (vSMCs) differentiation and quiescence
  • modulates the motility and resolution responses of macrophages
  • role of the syndecan (SDC1) heparan sulphate proteoglycans, the small intracellular adaptor SDCBP and associated regulators in the biogenesis and loading of exosomes with cargo
  • may modulate fibronectin fibrillogenesis and/or alter cell morphology during ECM production
  • soluble (shed) form of SDC1 has paracrine and autocrine functions and is normally produced in a regulated fashion
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • WNT
  • SDC1 and CASPR4, are potential TIAM1 PDZ domain binding proteins
  • SDC1 restrains migration in lung epithelium by activating RAP1A to slow focal adhesion disassembly
  • tyrosine phosphorylation of SDC1 triggers the robust recruitment of cortactin, which we found to be an essential mediator of efficient actin-dependent endocytosis
  • alternative binding of IL34 to chondroitin sulphates and SDC1 at the cell surface that modulates CSF1R activation
  • HPSE stimulates the exosomal secretion of SDCBP, SDC1 and certain other exosomal cargo, such as CD63, in a concentration-dependent manner
  • on epithelial tumor cells promotes MIF binding and MIF-mediated cell migration
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in an estrogen receptor-negative, highly proliferative breast carcinoma subtype
    constitutional     --low  
    before the clinical onset of preeclampsia, with reduced expression of SDC1 in the delivered placenta, suggesting a role for glycocalyx disturbance in preeclampsia pathophysiology
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • soluble SDC1 may be applicable as a surrogate marker of SLE disease activity
  • Therapy target
    SystemTypeDisorderPubmed
    immunologyautoimmuneLupus
    SDC1/TNFSF13 signaling may be a potential therapeutic target for patients with active SLE
    ANIMAL & CELL MODELS
  • Sdc1 -/- mice (Alexander (00))
  • Sdc1(-/-) mice are able to synthesize and maintain a hydrodynamically relevant glycocalyx, which indicates that syndecan-1 is not an essential anchoring protein for the glycocalyx