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FLASH GENE
Symbol SCYL3 contributors: - updated : 03-08-2005
HGNC name SCY1-like 3 (S. cerevisiae)
HGNC id 19285
Location 1q24.2      Physical location : 169.821.803 - 169.863.076
Synonym name
  • ezrin-binding partner PACE-1
  • Synonym symbol(s) PACE-1, PACE1
    DNA
    TYPE functioning gene
    STRUCTURE 40.00 kb     14 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 2874 76 688 - Sullivan
    - splicing 2794 82 742 - Sullivan
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  predominantly
    Reproductivefemale systemplacenta  moderately
    Urinarybladder   moderately
     kidney   moderately
    Visualeye   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervousperipherous   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal myristoylation consensus sequence
  • a protein kinase-like domain
  • four HEAT repeats
  • a C-terminal ezrin-binding domain
  • conjugated LipoP , PhosphoP , Other
    HOMOLOGY
    interspecies homolog to murine Scyl3
    Homologene
    FAMILY
    CATEGORY adhesion , enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,Golgi
    text
  • colocalized with VIL2/ezrin, actin and CD44 in lamellipodia
  • basic FUNCTION
  • may play a role in regulating cell adhesion/migration complexes in migrating cells
  • acting as a protein serine/threonine kinase
  • CELLULAR PROCESS cell migration & motility
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • myristoylated
  • INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • EZR/Ezrin C-terminal alpha-helical domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS