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FLASH GENE
Symbol SCYL2 contributors: mct - updated : 04-03-2013
HGNC name SCY1-like 2 (S. cerevisiae)
HGNC id 19286
Location 12q23.1      Physical location : 100.661.548 - 100.733.912
Synonym name a coated vesicle-associated kinase of 104 kDa
Synonym symbol(s) CVAK104, FLJ10074, KIAA1360
DNA
TYPE functioning gene
STRUCTURE 72.37 kb     18 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
18 - 3818 - 929 - 2005 15809293
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestivemouthtongue  moderately
Lymphoid/Immunelymph node   moderately
 thymus   highly
Reproductivefemale systemuterus  moderately
Urinarybladder   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a serine/threonine kinase homology domain
  • a C-terminal segment interacts with the N-terminal domain of clathrin and with the alpha-appendage of AP2
  • HOMOLOGY
    Homologene
    FAMILY SCY1-like family of protein kinases
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text
  • present on peripheral vesicular structures that are accessible to endocytosed transferrin
  • colocalizes with clathrin and adaptor protein-1 (AP-1), and it is associated with a transferrin-positive endosomal compartment
  • basic FUNCTION
  • acting as a protein serine/threonine kinase
  • function in clathrin-dependent pathways between the trans-Golgi network and the endosomal system
  • evolutionarily conserved protein involved in SNARE sorting that is essential for normal embryonic development
  • selectively induces intracellular accumulation of FZD5 via the clathrin-mediated pathway, which is suppressed by coexpression of a dominant negative form of RAB5A
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • selectively induces lysosomal degradation of FZD5
  • novel binding partner of Dishevelled (DVL), a scaffold protein in the Wnt signaling pathway
  • regulates the amount of FZD5 by inducing lysosomal degradation, which probably contributes to the suppression of the Wnt signaling pathway
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS