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FLASH GENE
Symbol SCUBE3 contributors: mct - updated : 27-08-2012
HGNC name signal peptide, CUB domain, EGF-like 3
HGNC id 13655
Location 6p21.31      Physical location : 35.182.189 - 35.218.609
Synonym name
  • CUB and EGF containing protein 3
  • CUB domain and EGF-like repeat containing 3
  • signal peptide, CUB and EGF-like domain containing protein 3
  • Synonym symbol(s) CEGF3, FLJ34743, DKFZp686B09105, DKFZp686B1223, DKFZp686D20108
    DNA
    TYPE functioning gene
    STRUCTURE 36.42 kb     22 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 5115 109.3 993 - 2004 15234972
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtooth  highly Mus musculusFetal
    Skeletonappendicular skeletonlower limbsfemur  
     appendicular skeletonupper limbhumerus  
    Skin/Tegumentskin appendageshairfollicle highly Mus musculusFetal
    Urinarykidney   highly Mus musculusFetal
    Visualeyelens   
     eyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    Connectivebone   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Skeletonosteoblast
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminal signal peptide sequence, multiple EGF-like domains,
  • a large spacer region containing multiple N-linked glycosylation sites
  • three repeated stretches of six-cysteine residues and
  • a C-terminal CUB domain
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • SCUBE gene family
  • CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • may be playing an important role in bone cell biology
  • may act locally and/or distantly through a proteolytic mechanism, and may play an important role in bone cell biology
  • may have a role in lung cancer progression (in lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFB receptor signaling and modulate EMT and cancer progression)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis , ossification
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    by promoter region methylation in primary renal cell carcinoma
    tumoral     --over  
    in lung cancer tumor tissues and is correlated with the invasive ability in a lung cancer cell line model
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS