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FLASH GENE

Symbol

SCUBE2

contributors: mct/pgu - updated : 24-09-2009

HGNC name	signal peptide, CUB domain, EGF-like 2
HGNC id	30425

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11p15.4      Physical location : 9.041.049 - 9.113.150
Synonym name	CEGP1 protein
Synonym symbol(s)	CEGP1, Cegb1, Cegf1, FLJ16792, FLJ35234, MGC133057

DNA

TYPE	functioning gene
STRUCTURE	71.22 kb     22 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_020974 22 - 3737 NP_066025 - 999 - 2009 19480626

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular vessel         Homo sapiens Nervous nerve cranial nerve optic nerve     Reproductive female system breast mammary gland     Homo sapiens   male system prostate       Urinary kidney         Homo sapiens Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining retinal pigment epithelium (RPE)     Epithelial secretory glandular     Homo sapiens

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell Homo sapiens not specific fibroblast Homo sapiens Reproductive epithelial cell Homo sapiens Urinary mesangial cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	five recognizable motifs: an N-terminal signal peptide sequence
	nine(EGF)-like repeats, that could mediate cell-cell homophilic adhesions in a calcium-dependent fashion, interact with CDH1 (a master tumor suppressor), and decrease the CTNNB signaling pathway
	a spacer region
	three cysteine-rich repeats
	and one CUB domain at the C-terminus, antagonizing autocrine BMP-mediated signaling

conjugated

GlycoP

mono polymer

homomer , heteromer , octamer

HOMOLOGY

interspecies	homolog to murine Scube2 (89.4pc)
	homolog to rattus Scube2 (89.5pc)

Homologene

FAMILY

SCUBE family

CATEGORY

tumor suppressor , signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	may play important roles in development, inflammation, and thrombosis
	positive component of the hedge hog signal, acting upstream of ligand binding at the plasma membrane
	has growth inhibitory effects through a coordinated regulation of two distinct mechanisms: antagonizing bone morphogenetic protein and suppressing the CTNNB pathway in breast cancer cells
	can act as a novel breast tumor suppressor gene

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development , inflammation

PATHWAY

metabolism

signaling

a component

forming homo-oligomers or hetero-oligomers with SCUBE1 or SCUBE3

INTERACTION

DNA

RNA

small molecule	metal binding,
	ions Ca2+

protein	interacting with SHH and its receptor PTCH1, enhancing the SHH signaling activity within the cholesterol-rich raft microdomains of the plasma membrane
	interacts and co-localizes with CDH1

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral       loss of function silenced or inactivated by similar regulatory mechanisms during breast cancer progression

Susceptibility

Variant & Polymorphism

Candidate gene	suppressing breast tumor cell proliferation and confers a favorable prognosis in invasive breast cancer
Marker
Therapy target

ANIMAL & CELL MODELS