Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SCT contributors: - updated : 18-02-2006
HGNC name secretin
HGNC id 10607
Location 11p15.5      Physical location : 626.312 - 627.173
Genatlas name secretin-derived from prosecretin
Synonym name
  • secretin preproprotein
    • Synonym symbol(s) SECR
    DNA
    TYPE like-sequence
    STRUCTURE 0.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    cytosine-phosphate-guanine/HTF
    Binding site
    motif repetitive sequence
    text structure
  • binding sites for SP-1, SP-3, AP-4 transcription factors
  • VWTR proximal to the promoter region
  • functional motifs including an E-box and 2 GC-boxes
    • MAPPING cloned Y linked N status provisional
    Map see INS
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestinesmall intestineduodenum lowly
     intestinesmall intestinejejunum lowly
    Nervousbrain   lowly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prosecretin made of a signal peptide
  • the bioactive mature secretin
  • a C terminal tail
    • HOMOLOGY
    interspecies homolog to murine Sct
    Homologene
    FAMILY glucagon family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulating the secretion of bicarbonate-rich pancreatic fluids and inhibiting HCL production by the stomac
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by the Sp1/Sp3 ratio and the methylation status of the promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autistic disorders
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS