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FLASH GENE
Symbol SCT contributors: - updated : 18-02-2006
HGNC name secretin
HGNC id 10607
Location 11p15.5      Physical location : 626.312 - 627.173
Genatlas name secretin-derived from prosecretin
Synonym name
  • secretin preproprotein
  • Synonym symbol(s) SECR
    DNA
    TYPE like-sequence
    STRUCTURE 0.00 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    cytosine-phosphate-guanine/HTF
    Binding site
    motif repetitive sequence
    text structure
  • binding sites for SP-1, SP-3, AP-4 transcription factors
  • VWTR proximal to the promoter region
  • functional motifs including an E-box and 2 GC-boxes
  • MAPPING cloned Y linked N status provisional
    Map see INS
    Physical map
    IFITM1 11p15.5 interferon induced transmembrane protein 1 (9-27) IFITM3 11p15.5 interferon induced transmembrane protein 3 (1-8U) PKP3 11p15 plakophilin 3 LOC387734 11 similar to beta 1,4-N-acetylgalactosaminyltransferase-transferase-III FLJ25045 11p15.5 hypothetical protein FLJ25045 SIGIRR 11p15.5 single Ig IL-1R-related molecule PTDSS2 11p15 phosphatidylserine synthase 2 RNH 11p15.5 ribonuclease/angiogenin inhibitor LOC387735 11 similar to Collagen alpha 1(V) chain precursor HRAS 11p15.5 v-Ha-ras Harvey rat sarcoma viral oncogene homolog DKFZp761L1518 11p15.5 hypothetical protein DKFZp761L1518 MGC35138 11p15.5 hypothetical protein MGC35138 C11orf13 11p15,5 chromosome 11 open reading frame 13 KIAA1542 11p15.5 CTD-binding SR-like protein rA9 IRF7 11p15,5 interferon regulatory factor 7 MUCDHL 11p15,5 mucin and cadherin-like SCT 11p15.5 secretin DRD4 11p15.5 dopamine receptor D4 LOC387736 11 LOC387736 DEAF1 11p15,5 deformed epidermal autoregulatory factor 1 (Drosophila) LOC283232 11p15.5 hypothetical protein LOC283232 EPS8L2 11p15.5 EPS8-like 2 TALDO1 11p15.5-p15.4 transaldolase 1 FLJ34283 11p15.5 hypothetical protein FLJ34283 NS3BP 11p15.5 NS3BP BM88 11p15.5 NS3BP SLC25A22 11p15.5 solute carrier family 25 (mitochondrial carrier: glutamate), member 22 LOC387737 11 LOC387737 LRDD 11pter-p15.5 leucine-rich and death domain containing RPLP2 5q31 ribosomal protein, large P2 TTS-2.2 11p15.5 transport-secretion protein 2.2 MGC45840 11p15.5 hypothetical protein MGC45840 CD151 11p15.5 CD151 antigen POLR2L 11p15 polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa TM4SF7 11p15.5 transmembrane 4 superfamily member 7 MGC3234 11p15.5 hypothetical protein MGC3234
    RNA
    TRANSCRIPTS type messenger
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    blood / hematopoieticspleen    
    Digestiveintestinesmall intestineduodenum lowly
     intestinesmall intestinejejunum lowly
    Nervousbrain   lowly
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Lymphoid    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • prosecretin made of a signal peptide
  • the bioactive mature secretin
  • a C terminal tail
  • HOMOLOGY
    interspecies homolog to murine Sct
    Homologene
    FAMILY glucagon family
    CATEGORY signaling hormone
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • stimulating the secretion of bicarbonate-rich pancreatic fluids and inhibiting HCL production by the stomac
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS digestion
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other regulated by the Sp1/Sp3 ratio and the methylation status of the promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to autistic disorders
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS