Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SCRT1

contributors: - updated : 16-01-2007

HGNC name	scratch homolog 1, zinc finger protein (Drosophila)
HGNC id	15950

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8q24.3      Physical location : 145.554.453 - 145.559.943
Synonym name	scratch
Synonym symbol(s)	SCRT, SCRATCH1

DNA

TYPE	functioning gene
STRUCTURE	5.00 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain           nerve cranial nerve       Visual eye retina

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous central       Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage
cell lines	lung cancers with neuroendocrine features, especially small cell lung cancer
fluid/secretion

at STAGE

physiological period

embryo, fetal

Text	newly differentiating neurons, fetal eyes, lens, eye anterior segment, optic nerve, retina

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	12 C2H2-type zinc fingers
	a KRAB domain

HOMOLOGY

interspecies	homolog to murine Scrt1
	homolog to Drosophila scrt

Homologene

FAMILY

SNAIl family of C2H2-type zinc finger transcription factors

CATEGORY

regulatory , DNA associated , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	directly antagonizing the function of heterodimers of the proneural bHLH protein ASCL1C and E12 (TCF3), leading to active transcriptional repression at E-box motifs
	modulating the action of bHLH transcription factors critical for neuronal differentiation
	may promote neural differention and may be involved in cancers with neuroendocrine features
	may be involved in transcriptional regulation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA	binding to E-box enhancer motifs

RNA

small molecule	metal binding,
	zinc Zn2+

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS