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FLASH GENE
Symbol SCRT1 contributors: - updated : 16-01-2007
HGNC name scratch homolog 1, zinc finger protein (Drosophila)
HGNC id 15950
Location 8q24.3      Physical location : 145.554.453 - 145.559.943
Synonym name scratch
Synonym symbol(s) SCRT, SCRATCH1
DNA
TYPE functioning gene
STRUCTURE 5.00 kb     2 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
CYC1 8q24.3 cytochrome c-1 DKFZP434N1923 8q24.3 hypothetical protein DKFZp434N1923 MAF1 8q24.3 homolog of yeast MAF1 KIAA1875 8q24.3 hypothetical protein KIAA1875 LOC51236 8q24.3 brain protein 16 LOC392276 8 similar to RIKEN cDNA 1700091F14 LOC392277 8 similar to RIKEN cDNA 1700091F14 KIAA1833 8q24.3 hypothetical protein KIAA1833 BOP1 8q24.3 block of proliferation 1 HSF1 8q24.3 heat shock transcription factor 1 DGAT1 8q24.3 diacylglycerol O-acyltransferase homolog 1 (mouse) DKFZp547F072 8q24.3 hypothetical protein DKFZp547F072 SCRT1 8q24.3 scratch homolog 1, zinc finger protein (Drosophila) LOC340393 8q24.3 similar to unnmaed protein product FBXL6 8q24-q25 F-box and leucine-rich repeat protein 6 FLJ11856 8q24.3 putative G-protein coupled receptor GPCR41 ADCK5 8q24.3 aarF domain containing kinase 5 CPSF1 8q24-q23 cleavage and polyadenylation specific factor 1, 160kDa SLC39A4 8q24.3 solute carrier family 39 (zinc transporter), member 4 VPS28 8q24.3 vacuolar protein sorting 28 (yeast) NFKBIL2 8q24.3 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 MGC13010 8q24.3 hypothetical protein MGC13010 KIFC2 8q24.3 likely ortholog of mouse kinesin family member C2 FOXH1 8q24.3 forkhead box H1 PPP1R16A 8q24.3 protein phosphatase 1, regulatory (inhibitor) subunit 16A GPT 8q24.3 glutamic-pyruvate transaminase (alanine aminotransferase) LOC113655 8q24.3 hypothetical protein BC011982 RECQL4 8q24.3 RecQ protein-like 4 KIAA0014 8q24.3 RecQ protein-like 4
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
 nervecranial nerve   
Visualeyeretina   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
Nervousperipherous   
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines lung cancers with neuroendocrine features, especially small cell lung cancer
fluid/secretion
at STAGE
physiological period embryo, fetal
Text newly differentiating neurons, fetal eyes, lens, eye anterior segment, optic nerve, retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • 12 C2H2-type zinc fingers
  • a KRAB domain
    • HOMOLOGY
    interspecies homolog to murine Scrt1
    homolog to Drosophila scrt
    Homologene
    FAMILY SNAIl family of C2H2-type zinc finger transcription factors
    CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • directly antagonizing the function of heterodimers of the proneural bHLH protein ASCL1C and E12 (TCF3), leading to active transcriptional repression at E-box motifs
  • modulating the action of bHLH transcription factors critical for neuronal differentiation
  • may promote neural differention and may be involved in cancers with neuroendocrine features
  • may be involved in transcriptional regulation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to E-box enhancer motifs
    RNA
    small molecule metal binding,
    zinc Zn2+
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS