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FLASH GENE
Symbol SCRN1 contributors: mct - updated : 25-02-2008
HGNC name secernin 1
HGNC id 22192
Location 7p14.3-p14.1      Physical location : 29.959.719 - 30.029.905
Synonym symbol(s) KIAA0193, SES1
DNA
TYPE functioning gene
STRUCTURE 69.00 kb     8 Exon(s)
MAPPING cloned   linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
8 - 5226 - 414 - Suda (2006)
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
 pancreas exocrine   highly
Endocrineneuroendocrinepituitary  highly
 parathyroid   highly
Lymphoid/Immunelymph node   highly
Nervousbrain   highly
Reproductivefemale systemuteruscervix highly
Respiratorylung   highly
 respiratory tractlarynx  highly
Skin/Tegumentskin   highly
Visualeye   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies ortholog to murine Scrn1
Homologene
FAMILY secernin family
CATEGORY enzyme , regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • regulating exocytosis in mast cells
  • increasing the extent of secretion and the
  • sensitivity of mast cells to stimulation with calcium
  • acting as a dipeptidase
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS exocytosis transport
    PATHWAY
    metabolism other
    signaling
    proteolysis and peptidolysis
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS