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FLASH GENE
Symbol SCOC contributors: mct - updated : 30-05-2015
HGNC name short coiled-coil protein
HGNC id 20335
Location 4q31.1      Physical location : 141.178.439 - 141.303.710
Synonym symbol(s) HRIHFB2072, SCOCO
DNA
TYPE functioning gene
STRUCTURE 125.27 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
LOC391701 4 similar to ribosomal protein S23 SLC7A11 4q28-q32 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 LOC152594 4q28.3 similar to ART-4 protein CCRN4L 4q28.3 CCR4 carbon catabolite repression 4-like (S. cerevisiae) ELF2 4q28 E74-like factor 2 (ets domain transcription factor) LOC389224 4 hypothetical gene supported by AK097799 OSAP 4q31.1 ovary-specific acidic protein NDUFC1 4q28.2-q28.3 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa TBDN100 4q31.1 transcriptional coactivator tubedown-100 RAB33B 4q28 RAB33B, member RAS oncogene family SET7 4q28 SET domain-containing protein 7 MGST2 4q28-q31 microsomal glutathione S-transferase 2 MAML3 4q28 mastermind-like 3 (Drosophila) SCOC 4q28.3 short coiled-coil protein LOC391702 4 similar to ribosomal protein L14; 60S ribosomal protein L14 CLGN 4q28.3-q31.1 calmegin LOC152586 4q31.1 similar to RIKEN cDNA 4933434I20 MGC10084 4q31.1 hypothetical protein MGC10084 UCP1 4q28-q31 uncoupling protein 1 (mitochondrial, proton carrier) KIAA0882 4q31.1 KIAA0882 protein LOC389225 4 LOC389225 LOC389226 4 similar to ring finger protein 130; g1-related zinc finger protein RNF150 4q31.1 ring finger protein 150 LOC389227 4 LOC389227 ZNF330 4q31.1-q31.2 LOC389227 LOC389228 4 similar to GRIK2 protein IL15 4q31 interleukin 15 INPP4B 4q31.11 inositol polyphosphate-4-phosphatase, type II, 105kDa USP38 4q31.1 ubiquitin specific protease 38 GAB1 4q31.4-q13.5 GRB2-associated binding protein 1 SMARCA5 4q31.1-q31.2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 LOC389229 4 similar to Beta-glucuronidase precursor (Beta-G1) LOC166752 4q31.1 similar to embryonic blastocoelar extracellular matrix protein precursor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
5 - 1876 - 122 - 2010 2081276
5 - 1873 - 121 - 2010 2081276
4 - 2009 - 122 - 2010 2081276
3 - 1925 - 94 - 2010 2081276
4 - 1969 - 159 - 2010 2081276
4 - 1966 - 158 - 2010 2081276
3 - 1885 - 131 - 2010 2081276
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneB cell
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal
Text brain
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Scoc
homolog to rattus LOC364981
Homologene
FAMILY
CATEGORY unknown/unspecified
SUBCELLULAR LOCALIZATION     plasma membrane
    intracellular
intracellular,cytoplasm,organelle,membrane
intracellular,cytoplasm,organelle,Golgi
intracellular,cytoplasm,organelle,endosome
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • may be an effector of ARL1 protein
  • required for autophagosome formation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • SCOC forms a complex with fasciculation and elongation protein zeta 1 (FEZ1)
  • SCOC forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ARL1
  • forms a stable homogeneous complex with the coiled coil domain of FEZ1
  • cell & other
    REGULATION
    Other brefeldin A induces its dissociation from Golgi
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS