Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SCN3A contributors: mct - updated : 01-09-2010
HGNC name sodium channel, voltage-gated, type III, alpha
HGNC id 10590
Corresponding disease
DEL2Q24 chromosome 2 interstitial deletion, including sub-band 2q24.3
Location 2q24.3      Physical location : 165.944.031 - 166.060.577
Synonym name
  • sodium channel, voltage-gated, type III, alpha polypeptide
  • brain III voltage-gated sodium channel
  • Synonym symbol(s) NAC3, NAv1.3, KIAA1356
    DNA
    TYPE functioning gene
    SPECIAL FEATURE head to head, opposite orientation
    text oriented head to head with SCN2A1
    STRUCTURE 116.60 kb     28 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TANK 2q24-q31 TRAF family member-associated NFKB activator PSMD14 2q24.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 TBR1 2q24 T-box, brain, 1 LOC285116 2q24.3 ELYS transcription factor-like protein TMBS62 pseudogene LOC391458 2 similar to Keratin, type I cytoskeletal 18 (Cytokeratin 18) (K18) (CK 18) SLC4A10 2q23-q24 solute carrier family 4, sodium bicarbonate transporter-like, member 10 DPP4 2q24.3 dipeptidylpeptidase 4 (CD26, adenosine deaminase complexing protein 2) GCG 2q36-q37 glucagon FAP 2q23 fibroblast activation protein, alpha MDA5 2p24.3-q24.3 melanoma differentiation associated protein-5 GCA 2q24.3 grancalcin, EF-hand calcium binding protein KCNH7 2q24.3 potassium voltage-gated channel, subfamily H (eag-related), member 7 FIGN 2q24.2 fidgetin GRB14 2q22-q24 growth factor receptor-bound protein 14 KIAA0977 2q24.3 growth factor receptor-bound protein 14 FLJ39822 2q24.3 hypothetical protein FLJ39822 SCN3A 2q24.3 sodium channel, voltage-gated, type III, alpha SCN2A2 2q23-q24.3 sodium channel, voltage-gated, type II, alpha 2 TAIP-2 2q24.3 TGF-beta induced apotosis protein 2 GALNT3 2q24-q31 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3) FLJ11457 2q31.1 hypothetical protein FLJ11457 SCN1A 2q24 sodium channel, voltage-gated, type I, alpha SCN9A 2q24 sodium channel, voltage-gated, type IX, alpha SCN7A 2q21-q23 sodium channel, voltage-gated, type VII, alpha CMYA3 2q31.1 cardiomyopathy associated 3 LOC90643 2q31.1 similar to Meningioma-expressed antigen 6/11 (MEA6) (MEA11) B3GALT1 2q24.3 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 STK39 2q24.3 serine threonine kinase 39 (STE20/SPS1 homolog, yeast) LOC253782 2q31.1 hypothetical protein LOC253782 NOSTRIN 2q31.1 nitric oxide synthase trafficker AD024 IGRP 2q24-q31 nitric oxide synthase trafficker ABCB11 2q24.1 ATP-binding cassette, sub-family B (MDR/TAP), member 11 DHRS9 2q31.1 dehydrogenase/reductase (SDR family) member 9 LRP2 2q31-q32.1 low density lipoprotein-related protein 2 DKFZp762I194 2q31.1 hypothetical protein DKFZp762I194 SARCOSIN 2q31.1 hypothetical protein DKFZp762I194 FLJ21901 2q31 hypothetical protein FLJ21901
    RNA
    TRANSCRIPTS type messenger
    text with two isoforms (neonatal and adult) (Lu)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    28 - 9141 226.3 2000 - -
    28 - 8994 221.5 1951 - -
    28 - 8994 221.5 1951 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane domains of homology,each with six alpha helical membrane spanning segments,and two cytoplasmic loops
  • one IQ domain
  • C-terminal residue that regulates the kinetics and voltage dependence of fast inactivation in sodium channels, possibly via a charge-dependent interaction with the inactivation linker (Nguyen 2010)
  • HOMOLOGY
    interspecies homolog to murine Scn3a
    intraspecies homolog to SCN2A1
    Homologene
    FAMILY
  • sodium channel gene family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • neuronal channel that are essential for the initiation and propagation of action potentials in the CNS and PNS (Meisler 2010)
  • with SCN2A, and SCN9A, likely account for the tetrodotoxin-sensitive sodium currents in taste receptor cells (Gao 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
  • protein constituent of membrane
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DEL2Q24
    Susceptibility to epilepsy
    Variant & Polymorphism other mutation linked to epilepsy increases ramp and persistent current of SCN3A and induces hyperexcitability in hippocampal neurons (Holland 2008)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS