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Symbol SCN10A contributors: mct/npt/pgu - updated : 16-03-2018
HGNC name sodium channel, voltage-gated, type X, alpha subunit
HGNC id 10582
Corresponding disease
FEPS2 episodic pain syndrome, familial, 2
Location 3p22.2      Physical location : 38.738.837 - 38.835.501
Synonym name
  • sodium channel, voltage-gated, type X, alpha polypeptide
  • voltage-gated sodium channel subunit alpha Nav1.8
  • peripheral nerve sodium channel 3
  • Synonym symbol(s) Nav1.8, hPN3, SNS, PN3
    TYPE functioning gene
    STRUCTURE 96.66 kb     27 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CTDSPL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like VILL 3p21.3 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like PLCD1 3p21.3 phospholipase C, delta 1 DLEC1 ACAA1 3p23-p22 acetyl-Coenzyme A acyltransferase 1 (peroxisomal 3-oxoacyl-Coenzyme A thiolase) MYD88 3p22-p21.3 myeloid differentiation primary response gene (88) OSR1 3p22-p21.3 oxidative-stress responsive 1 SLC22A13 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 13 SLC22A14 3p22-p21.3 solute carrier family 22 (organic cation transporter), member 14 XYLB 3p22-p21.3 xylulokinase homolog (H. influenzae) ACVR2B 3p22 activin A receptor, type IIB ENDOGL1 3p21.3 endonuclease G-like 1 LOC391528 3 similar to ribosomal protein L18a; 60S ribosomal protein L18a SCN5A 3p21 sodium channel, voltage-gated, type V, alpha (long QT syndrome 3) SCN10A 3p21-p22 sodium channel, voltage-gated, type X, alpha SCN11A 3p24-p21 sodium channel, voltage-gated, type XI, alpha KIAA1449 3p21.33 WD repeat endosomal protein GORASP1 3p22-p21.33 golgi reassembly stacking protein 1, 65kDa STI2 3p21.33 TPR domain containing STI2 AXUD1 3p22 AXIN1 up-regulated 1 CMYA1 3p21.33 cardiomyopathy associated 1 CX3CR1 3p21.32-p21.31 chemokine (C-X3-C motif) receptor 1 CCR8 3p21.32-p21.31 chemokine (C-C motif) receptor 8 hnRNPA1p 3p21.33 heterogeneous nuclear ribonucleoprotein A1 pseudogene LOC389109 3 similar to elongation factor 1 alpha LOC389110 3 similar to Elongation factor 1-alpha 1 (EF-1-alpha-1) (Elongation factor 1 A-1) (eEF1A-1) (Elongation factor Tu) (EF-Tu) LOC389111 3 similar to RIKEN cDNA 1110038F21 FLJ20551 3p21.33 hypothetical protein FLJ20551
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    27 - 5874 - 1956 - 2010 19953341
    Type restricted
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheartconducting system    Homo sapiensAdult
    Nervousgangliasensory gangliadorsal root highly Homo sapiensAdult
     nervespinal nervesciatic  
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    at STAGE
  • four transmembrane domains of homology, each with six alpha helical membrane spanning segments, and two cytoplasmic loops
  • an Iq domain
  • sodium channel family
  • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • voltage-gated, type X,tetrodotoxin resistant, specific to sensory neurons
  • mediates the voltage-dependent sodium ion permeability of excitable membranes
  • contributes a substantial fraction of the current underlying the depolarizing phase of the action potential of dorsal root ganglion (DRG) neurons
  • plays a role in neuropathic pain mechanisms
  • have a central role in the propagation of action potentials in nociceptive nerve fibers
  • may play a role in different pain conditions, and its signaling might be involved in visceral pain
  • modulatory role in the development of cold, but not mechanical allodynia in neuropathic pain conditions
  • function in the transmission of pain signals induced by cold, heat, and mechanical stimuli
  • implicated in modulating the activity of CNS neurons
  • implicated in transducing pain initiated by cold and additionally implicate SCN10A in previously unknown functions in the central nervous system and heart
  • activation of ASIC3 and TRPV1 as well as enhanced SCN10A activity are essential for the development of long-lasting hyperalgesia in acid-induced, chronic, widespread muscle pain
    a component
  • protein constituent of membrane
    small molecule
  • binding SCLT1
  • interacting with calmodulin (in native neurons, implicated in the regulation of SCN10A currents that can significantly affect electrogenesis of dorsal root ganglion neurons in which SCN10A is normally expressed)
  • interacting with AQP1 (Aquaporin-1 tunes pain perception by interaction with SCN10A in dorsal root ganglion neurons)
  • KIF5B is required for the forward transport and axonal function of SCN10A, suggesting a mechanism for axonal accumulation of SCN10A in inflammatory pain
  • cell & other
    corresponding disease(s) FEPS2
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    may be one of the pathophysiological mechanisms involved in limb lengthening-induced neuropathy
  • to heart block
  • to Brugada syndrome
  • Variant & Polymorphism other
  • rs6795970 is associated with a higher risk of heart block and a lower risk of ventricular fibrillation
  • variants at SCN5A-SCN10A associated with Brugada syndrome
  • Candidate gene
    Therapy target
  • PR interval is shorter in Scn10a-/-mice than in wild-type mice
  • dominant neurobehavioral phenotype termed Possum, characterized by transient whole-body tonic immobility induced by pinching the skin at the back of the neck (“scruffing”)