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FLASH GENE
Symbol SCLY contributors: npt/SGE - updated : 25-09-2019
HGNC name selenocysteine lyase
HGNC id 18161
Location 2q37.3      Physical location : 238.969.631 - 239.008.053
Synonym name putative selenocysteine lyase
Synonym symbol(s) SCL, hSCL
EC.number 4.4.1.16
DNA
TYPE functioning gene
STRUCTURE 38.42 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
Physical map
COPS8 2q37.3 COP9 constitutive photomorphogenic homolog subunit 8 (Arabidopsis) LOC389087 2 LOC389087 COL6A3 2q37.3 collagen, type VI, alpha 3 LOC285110 2q37.3 hypothetical LOC285110 MLPH 2q37.3 hypothetical LOC285110 PRH 2q37.3 preproprolactin-releasing peptide RAB17 2q37.3 RAB17, member RAS oncogene family LRRFIP1 2q37.3 leucine rich repeat (in FLII) interacting protein 1 FLJ40411 2q37.3 FLJ40411 protein RAMP1 2q36-q37.1 receptor (calcitonin) activity modifying protein 1 NCE2 2q37.3 NEDD8-conjugating enzyme SCLY 2q37.3 selenocysteine lyase LOC339768 2q37.3 hypothetical protein LOC339768 FLJ43374 2q37.3 FLJ43374 protein LOC389088 2 similar to hypothetical protein 4832406C22 ILKAP 2q37.3 integrin-linked kinase-associated serine/threonine phosphatase 2C LOC151174 2q37.3 hypothetical protein LOC151174 LOC391494 2 similar to TAR DNA-binding protein-43 (TDP-43) HES6 2q37.3 hairy and enhancer of split 6 (Drosophila) PER2 2q37.3 period homolog 2 (Drosophila) MIP-T3 2q37.3 microtubule-interacting protein that associates with TRAF3 ASB1 2q37 ankyrin repeat and SOCS box-containing 1 LOC339771 2q37.3 hypothetical LOC339771 HDAC4 2q37.2 histone deacetylase 4 MGC16025 2q37.3 hypothetical protein MGC16025 LOC389089 2 LOC389089
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 2477 - 445 - 2000 10692412
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Digestiveliver    
 mouthtongue  lowly
 pancreas exocrine    
Nervousbrain   highly Homo sapiens
Urinarykidney    
Visualeyeretinafovea lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines neuroblastoma
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to murine Scly (82.6pc)
homolog to rattus Scly (82.4pc)
Homologene
FAMILY
  • class-v pyridoxal-phosphate-dependent aminotransferase family
  • nifs/iscs subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    basic FUNCTION
  • selenocysteine lyase activity
  • catalyzing the removal of elemental sulfur from cysteine to produce alanine
  • supplying the inorganic sulfur for iron- sulfur (fe-s) clusters
  • catalyzes the pyridoxal 5'-phosphate-dependent removal of selenium from l-selenocysteine to yield l-alanine
  • SCLY and SELENOP work cooperatively to maintain selenoprotein function in the mammalian brain
  • SCLY has a remarkable effect on obesity and metabolic syndrome development triggered by high-fat exposure, independent of the expression of most selenoproteins
  • works as a homodimer, utilizing pyridoxal 5'-phosphate as a cofactor, and catalyzing the specific decomposition of the amino acid selenocysteine into alanine and selenide
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism aminoacid
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • pyridoxal phosphate
  • protein
  • SCLY disruption increases the levels of insulin-signaling inhibitor PTPN1
  • cell & other
    REGULATION
    Other regulated by AP-1
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • may be involved in the pathophysiology of hepatocellular carcinoma (Yepes 2006)
  • up-regulated in acute glomerulonephritis
  • Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the Scly gene in mice led to obesity, hyperinsulinemia, glucose intolerance, and hepatic steatosis