Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SCLT1

contributors: mct - updated : 19-06-2014

HGNC name	sodium channel and clathrin linker 1
HGNC id	26406

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	4q28.2      Physical location : 129.805.151 - 130.014.764
Synonym name	clathrin-associated protein-1A
Synonym symbol(s)	FLJ30655, FLJ36042, MGC70542, hCAP-1A

DNA

TYPE	functioning gene
STRUCTURE	209.62 kb     21 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_144643 21 - 3053 NP_653244 - 688 - 2005 15797711

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive pharynx       highly Hearing/Equilibrium ear inner cochlea   highly Nervous nerve cranial nerve     highly

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

distinct domains that bind SCN10A and clathrin

HOMOLOGY

Homologene

FAMILY

CATEGORY

adaptor , transport channel

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,nucleus

basic FUNCTION	adapter protein that links clathrin and a sodium channel and may regulate SCN10A channel density at the cell surface
	essential component of the distal appendages, a centrosomal extension that establishes the connection between the mother centriole and the plasma membrane

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binds clathrin and the voltage-gated sodium channel SCN10A
	CEP83 recruits both SCLT1 and CEP89 to centrioles

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene	for OFD9
Marker
Therapy target

ANIMAL & CELL MODELS