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FLASH GENE
Symbol SCGN contributors: mlc - updated : 23-11-2007
HGNC name secretagogin, EF-hand calcium binding protein
HGNC id 16941
Location 6p22.3-p22.1      Physical location : 25.652.428 - 25.702.006
Synonym name
  • calbindin-like
  • setagin
  • hexa-EF-hand calcium binding protein
    • Synonym symbol(s) SEGN, SECRET, DJ501N12.8, CALBL, setagin
    DNA
    TYPE anonymous DNA segment
    SPECIAL FEATURE opposite orientation
    STRUCTURE 49.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    text structure promoter sequence showed subtle but significant regulation by glucose within the normo-physiological range
    MAPPING cloned   linked   status
    RNA
    TRANSCRIPTS type
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 1492 - 276 in pancreas, in the central nervous system and organs containing neurendocrine cells Skovhus (2006)
    - - - - - in pancreas, in the central nervous system and organs containing neurendocrine cells Zierhut (2005)
    one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing
    - - 705 - 49 only in pancreas Zierhut (2005)
    due to a frame shift, only the first 27 amino acids are identical to secretagogin
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon  
    Endocrineneuroendocrinepituitary   
     pancreas    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialabsorptive excretorydigestive epithelium (mucosa) highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • calcium-binding protein
  • may be involved in KCL-stimulated calcium flux and cell proliferation
  • being novel marker for neuroendocrine differentiation.
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in serum after ischemic neuronal damage
    tumoral     --over  
    in the cytosol and the nucleus of well-differentiated neuroendocrine carcinoids and carcinoid metastases, as well as in neuroendocrine tumors from the lung, pancreas and adrenal gland
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS