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FLASH GENE
Symbol SCGB3A1 contributors: mct - updated : 10-06-2009
HGNC name secretoglobin, family 3A, member 1
HGNC id 18384
Location 5q35.3      Physical location : 180.017.105 - 180.018.487
Synonym name
  • cytokine high in normal-1
  • uteroglobin-related protein 2
  • pneumo secretory protein 2
  • Synonym symbol(s) HIN1, UGRP2, HIN-1, LU105, MGC87867, PnSP-2, UGRP2
    DNA
    TYPE functioning gene
    STRUCTURE 1.38 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence cytosine-phosphate-guanine/HTF
    Binding site
    motif repetitive sequence   triplet
    text structure
  • methylation of CPG breast cancer cell lines
  • STAT-binding element (SBE) that plays an important role in the suppression of SCGB3A1 promoter activity by IFNG
  • MAPPING cloned Y linked N status provisional
    Physical map
    HNRPH1 5q353 heterogeneous nuclear ribonucleoprotein H1 (H) LOC202404 5q35.3 hypothetical LOC202404 LOC285679 5q35.3 hypothetical protein LOC285679 LOC389352 5 similar to High mobility group protein 4 (HMG-4) (High mobility group protein 2a) (HMG-2a) CANX 5q35 calnexin MAML1 5q35 mastermind-like 1 (Drosophila) FLJ12121 5q35.3 hypothetical protein FLJ12121 LTC4S 5q35 leukotriene C4 synthase MGAT4B 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B SQSTM1 5q35 sequestosome 1 LOC51149 5q35.3 truncated calcium binding protein KIAA0676 5q35.1-q35.3 truncated calcium binding protein RNF130 5q35.3 ring finger protein 130 LOC255426 LOC391860 5 similar to 40S ribosomal protein S8 MAPK9 5q35 mitogen-activated protein kinase 9 GFPT2 5q34-q35 glutamine-fructose-6-phosphate transaminase 2 KIAA1194 5q35.3 Homo sapiens KIAA1194 (KIAA1194), mRNA. SCGB3A1 5q35-qter secretoglobin, family 3A, member 1 FLT4 5q35.3 fms-related tyrosine kinase 4 LOC134082 5q35.3 similar to seven transmembrane helix receptor LOC134083 5q35.3 similar to Olfactory receptor 2Y1 MGAT1 5q35 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase FLJ21458 5q35.3 hypothetical protein FLJ21458 LOC391861 5 similar to cAMP-regulated phosphoprotein 19 (ARPP-19) BTNL3 5q35 butyrophilin-like 3 FLJ32535 5q35.3 butyrophilin 3 FOXO1B 5q35.2-q35.3 forkhead box O1B LOC340050 5q35.3 similar to hypothetical protein LOC340052 5q35.3 similar to seven transmembrane helix receptor LOC285659 5q35.3 similar to Olfactory receptor 2V3 LOC389353 5 LOC389353 TRIM7 5q35.3 tripartite motif-containing 7 TRIM41 5q35.3 tripartite motif-containing 41 GNB2L1 5q35.3-qter guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 FLJ23053 5q35.3 hypothetical protein FLJ23053 TRIM52 5q35.3 tripartite motif-containing 52 LOC389354 5 hypothetical gene supported by AL137733 LOC389355 5 similar to bA476I15.3 (novel protein similar to septin) LOC391862 5 similar to Olfactory receptor 4F3
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 517 9.97 104 - 2004 15383627
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas     Homo sapiens
    Reproductivefemale systembreast    Homo sapiens
     male systemprostate    Homo sapiens
    Respiratorylung   predominantly Homo sapiens
     respiratory tracttrachea  predominantly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial   highly Homo sapiens
    cell lineage
    cell lines
    fluid/secretion salivary
    at STAGE
    physiological period embryo
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 20 AA putative signal peptide
  • mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to Drosophila hin1
    intraspecies homolog to uteroglobin
    Homologene
    FAMILY
  • uteroglobin/Clara cell secretory protein family
  • UGRP subfamily
  • CATEGORY secretory , tumor suppressor , signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • playing a role in lobulogenesis, terminal differentiation and regulation of epithelial cell proliferation
  • potent inhibitor of anchorage-dependent and anchorage-independent cell growth, cell migration, and invasion
  • possesses tumor suppressor functions, and that these activities may be mediated through the AKT signaling pathway
  • may play crucial roles in inflammation and epithelial cell differentiation in lung
  • involved in the regulation of local immune responses in the lung
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    inhibited by by IFNG in lung epithelial cells via the binding of STAT1 to the SBE located in the SCGB3A1 gene promoter
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       loss of function
    in breast carcinoma and in preinvasive lesions (ductal and lobular carcinoma in situ)
    tumoral       loss of function
    by hypermethylation in prostate and a significant fraction of lung and pancreatic carcinomas
    tumoral     --low  
    silenced due to methylation in a substantial fraction of breast, prostate, lung, and pancreatic carcinomas
    tumoral     --low  
    silencing is associated with dense promoter region hypermethylation in esophageal cancer (methylation is an early event in dysplastic transformation)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS