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FLASH GENE

Symbol

SCGB1A1

contributors: mct - updated : 08-04-2013

HGNC name	secretoglobin, family 1A, member 1 (uteroglobin)
HGNC id	12523

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	11q12.3      Physical location : 62.186.506 - 62.190.678
Synonym name	blastokinin, Clara cell secretory protein
	uteroglobin
	Clara cell 10-kDa protein
	urinary protein 1
	clara cells 10 kDa secretory protein
	clara cell phospholipid-binding protein
Synonym symbol(s)	CC10, CC16, UBG, CCSP, CCPBP, CCSP, UP-1, UP1

DNA

TYPE	functioning gene
STRUCTURE	4.17 kb     3 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

Y

status

confirmed

Map	see CD6 ,VMD2

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003357 3 - 452 NP_003348 - 91 - -

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine large intestine colon   highly   mouth tongue     moderately Reproductive male system prostate     moderately Respiratory lung       highly Homo sapiens Adult   respiratory tract trachea     moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / hematopoietic bone marrow     moderately Homo sapiens Adult Epithelial barrier/lining     moderately

cells

System Cell Pubmed Species Stage Rna symbol reproductive uterus

cell lineage
cell lines	clara cells (non ciliated cells of the pulmonary airways)
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to rattus Scgb1a1 (55.56 pc)
	homolog to murine Scgb1a1 (55.56 pc)

Homologene

FAMILY

antiflammin family (or uteroglobin family)

CATEGORY

signaling cytokine

SUBCELLULAR LOCALIZATION	extracellular
	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic,granule
	intracellular,nuclear envelope

basic FUNCTION	involved in embryo implantation
	acting as an inhibitor of phospholipase A2
	can attenuate inflammation through regulation of macrophage behavior, suggesting that epithelial remodeling leading to reduced Clara cell secretory function is an important factor that increases the intensity of lung inflammation in chronic lung disease
	cells with SCGB1A1 promoter activity that expresses vascular endothelial growth factor participates in alveolar development
	its gene transfer may inhibit airway inflammation through suppressing the activation of NFKB1, which may provide us a new consideration in the therapy of airway inflammation
	negatively regulate inflammation, protecting pulmonary surfactant from degradation in the lung

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

development

text	histogenesis and organogenesis

PATHWAY

metabolism

signaling

signal transduction

a component

antiparallel disulfide-linked homodimer

INTERACTION

DNA

RNA

small molecule

protein

binding to steroid (progesterone), phosphatidylcholine, phophatidylinositol, polychlorinated biphenyls (PCB)

cell & other

REGULATION

induced by

steroid (progesterone)

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional     --other   differentially expressed in infants with infant respiratory distress syndrome (iRDS)

Susceptibility

to asthma (see also IGER)

Variant & Polymorphism

Candidate gene	candidate for the development of a new immunotherapy for lung cancer
Marker
Therapy target

ANIMAL & CELL MODELS

proinflammatory state in mice homozygous for a null allele of the SCGB1A1 gene (SCGB1A1-/-) suggesting a central role for the nonciliated secretory cell in this process