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FLASH GENE
Symbol SCG3 contributors: mct - updated : 13-10-2012
HGNC name secretogranin III
HGNC id 13707
Location 15q21.2      Physical location : 51.973.549 - 52.013.222
Synonym symbol(s) SGIII, FLJ90833
DNA
TYPE functioning gene
STRUCTURE 39.67 kb     12 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
12 - 3366 52.9 468 - 2005 16219686
11 - 3313 - 236 - 2005 16219686
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainforebraincerebral cortex   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousglia Homo sapiens
not specificmast cell Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
interspecies homolog to murine Scg3
Homologene
FAMILY
  • chromogranin/secretogranin family
  • CATEGORY secretory
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    basic FUNCTION
  • closely associated with the secretory granule membrane, serving to anchor the aggregates of other soluble constituents to the membrane
  • involved in secretory granule biogenesis in mast cells
  • in mast cells, a Chromogranin-SCG3 complex may play a key role in secretory granule biogenesis
  • SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules
  • implicated in the astrocyte secretory pathway and its expression is finely regulated during glial activation
  • intracellular and extracellular roles for this glial granin in the physiology and repair/damage of neuronal circuits
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • was able to bind the aggregated form of CHGA, suggesting that a small quantity of SCG3 is enough to carry a large quantity of CHGA
  • has likely multiple binding partners, including the mast cell ion channel TRPA1
  • SCG2 interacts with SCG3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to metabolic syndrome
    Variant & Polymorphism other
  • variations influence the risk of metabolic syndrome
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS