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FLASH GENE
Symbol SCG2 contributors: mct - updated : 16-10-2012
HGNC name secretogranin II (chromogranin C)
HGNC id 10575
Location 2q36.1      Physical location : 224.461.659 - 224.467.217
Genatlas name manserin
Synonym name
  • EM66 precursor
  • manserin
  • Synonym symbol(s) CHGC, SG2
    DNA
    TYPE functioning gene
    STRUCTURE 5.56 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter (TATA box)
    Binding site   cAMP
    text structure consensus TATA box and cyclic AMP response element
    MAPPING cloned   linked   status provisional
    Physical map
    CHPF 2q36.1 chondroitin polymerizing factor LOC130612 2q36.1 similar to RIKEN cDNA A230078I05 gene KIAA0657 2q36.1 similar to RIKEN cDNA A230078I05 gene INHA 2q33-q34 inhibin, alpha STK11IP 2q36 serine/threonine kinase 11 interacting protein SLC4A3 2q36 solute carrier family 4, anion exchanger, member 3 EPHA4 2q36.1 EphA4 LOC130600 2q36.1 similar to ribosomal protein L23 LOC266724 2q36.3 heat shock 70kDa protein 9B pseudogene PAX3 2q36.1-q36.2 paired box gene 3 (Waardenburg syndrome 1) FLJ32447 2q36.1 hypothetical protein FLJ32447 SGPP2 2q36.3 sphingosine-1-phosphate phosphotase 2 FARSLB 2q36.1-q36.2 phenylalanine-tRNA synthetase-like, beta subunit DGAT2L1 2q36.3 diacylglycerol O-acyltransferase 2 like 1 LOC391486 2 similar to ribosomal protein L31 FACL3 2q34 fatty-acid-Coenzyme A ligase, long-chain 3 KCNE4 2q36.3 potassium voltage-gated channel, Isk-related family, member 4 SCG2 2q35-q36 secretogranin II (chromogranin C) LOC391487 2 similar to transcription factor-like protein 4 isoform beta; MAX-like bHLHZIP protein; MAX-like protein X; BigMax protein AP1S3 2q36.3 adaptor-related protein complex 1, sigma 3 subunit WDFY1 2q36.2 WD repeat and FYVE domain containing 1 MRPL44 2q36.3 mitochondrial ribosomal protein L44 SERPINE2 2q33-q35 serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 LOC391488 2 similar to Ubiquitin carboxyl-terminal hydrolase 21 (Ubiquitin thiolesterase 21) (Ubiquitin-specific processing protease 21) (Deubiquitinating enzyme 21) (NEDD8-specific protease) FLJ22746 2q36.3 hypothetical protein FLJ22746 CUL3 2q36.3 cullin 3 DOCK10 2q24.1-q36.3 dedicator of cytokinesis 10 KIAA1486 2q36.3 KIAA1486 protein IRS1 2q36 insulin receptor substrate 1 DKFZp547E052 2q36.3 hypothetical protein DKFZp547E052 COL4A4 2q35-q37.1 collagen, type IV, alpha 4 COL4A3 2q37.1 collagen, type IV, alpha 3 (Goodpasture antigen) LOC389077 2 LOC389077 GL004 2q37.1 LOC389077 FLJ22800 2q36.3 hypothetical protein FLJ22800 HRB 2q36 HIV-1 Rev binding protein
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 2586 - 617 - 2000 10648883
    - - - - 40 not only the brain but also the endocrine system such as the pituitary and adrenal glands, suggesting its role in the endocrine system 2010 20495819
  • neuropeptide derived from secretogranin II
  • occurring in the endocrine pancreas, may have a potential role in the endocrine system
  • EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineadrenal gland    
     neuroendocrinepituitary  highly
    Nervousbrainhindbraincerebellum highly Homo sapiens
     brainlimbic systemhippocampus highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron Homo sapiens
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text adrenal gland
    PROTEIN
    PHYSICAL PROPERTIES acid
    STRUCTURE
    motifs/domains
    acidic protein of secretory granules
    HOMOLOGY
    interspecies homolog to murine Scg2
    Homologene
    FAMILY chromogranin family
    CATEGORY transport
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    basic FUNCTION
  • involved in the packaging of sorting of peptide hormones and neuropeptider into secretory vesides
  • exerting a specific role in the neuroendocrine system
  • represents a key AP1-regulated protein that counteracts Nitric oxide toxicity and mediates neuronal differentiation of neuroblastoma cells
  • SCG2, as well as SCG3, may be a potential regulator of food intake based on its capacity to accumulate appetite-related hormones into secretory granules
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text vesicular transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    calcium Ca2+
    protein
  • aggregating in its presence,granin family,including a conserved peptide EM66 posttranslationally processed from CHGC in the adrenals,marker for neuronal differentiation in neuroblastoma cell lines
  • SCG2 interacts with SCG3
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    increased in patients with chronic, stable heart failure
    tumoral     --over  
    in endocrine pancreatic tumors with higher concentrations than patients with carcinoid tumors or pheochromocytomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • may represent a new cardiac biomarker
  • Therapy target
    ANIMAL & CELL MODELS