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FLASH GENE
Symbol SCD5 contributors: - updated : 27-02-2007
HGNC name stearoyl-CoA desaturase 5
HGNC id 21088
Location 4q21.22      Physical location : 83.550.689 - 83.720.010
Synonym name
  • acyl-CoA-desaturase 4
  • stearoyl-CoA desaturase 4
  • Synonym symbol(s) ACOD4, FLJ21032, FADS4, HSCD5, SCD2, SCD4
    DNA
    TYPE functioning gene
    STRUCTURE 169.00 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 3030 - 330 - Wang
    - - 2021 - 256 - Wang
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrineneuroendocrinepituitary  highly
     pancreas   highly
    Hearing/Equilibriumearinnercochlea highly
    Nervousbrain   highly
     nervecranial nerve  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text brain, kidney
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a histidine box domains may be containing the active site and/or be involved in metal ion binding
  • HOMOLOGY
    interspecies homolog to drosophila acyl-CoA desaturases
    homolog to murine Scd2
    intraspecies homolog to SCD1
    Homologene
    FAMILY fatty acid desaturase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    text co-localized with calnexin on ER membrane
    basic FUNCTION
  • catalyzing the committed step in the biosynthesis of monounsaturated fatty acids from saturated fatty acids
  • plays a role distinct from that of SCD1 during development and in normal physiological conditions
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    iron
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS