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FLASH GENE
Symbol SCARF2 contributors: mct - updated : 26-10-2010
HGNC name scavenger receptor class F, member 2
HGNC id 19869
Corresponding disease
VDEGS Van Den Ende-Gupta Syndrome
Location 22q11.21      Physical location : 20.778.874 - 20.792.146
Synonym name
  • scavenger receptor type F
  • scavenger receptor expressed by endothelial cells 2
  • Synonym symbol(s) SRECII, HUMZD58C02, SREC2, SRECRP-1
    DNA
    TYPE functioning gene
    STRUCTURE 13.27 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC388849 22 LOC388849 FLJ32575 22q11.21 hypothetical protein FLJ32575 RTN4R 22q11.21 reticulon 4 receptor LOC388850 22 similar to proline dehydrogenase (oxidase) 1; proline oxidase 2; p53 induced protein; tumor protein p53 inducible protein 6 DGCR6L 22q11.2 DiGeorge syndrome critical region gene 6-like LOC391297 22 LOC391297 LOC284859 22q11.21 hypothetical gene supported by BC039313 GGT2 22q11 gamma-glutamyltransferase 2 LOC284874 22q11.21 hypothetical LOC284874 LOC388851 22 similar to phosphatidylinositol 4-kinase, catalytic, alpha polypeptide isoform 2; phosphatidylinositol 4-kinase, type II, alpha; phosphatidylinositol 4-kinase, type III, alpha; phosphatidylinositol 4-kinase 230 LOC388852 22 similar to hypothetical protein LOC388853 22 similar to Sushi domain (SCR repeat) containing LOC391298 22 similar to KIAA0649 gene product LOC388854 22 similar to Gamma-glutamyltranspeptidase 1 precursor (Gamma-glutamyltransferase 1) (CD224 antigen) LOC388855 22 hypothetical gene supported by BC039313 LOC388856 22 hypothetical gene supported by BC039313 LOC388857 22 similar to KIAA0649 gene product LOC391299 22 similar to Collagen alpha 1(II) chain precursor USP41 22q11.22 ubiquitin specific protease 41 ZNF74 22q11.21 zinc finger protein 74 (Cos52) SCARF2 22q11.21 scavenger receptor class F, member 2 FLJ14360 22q11.21 hypothetical protein FLJ14360 PCQAP 22q11.21 PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein LOC391300 22 similar to hypothetical protein FLJ20297 LOC343839 22q11.21 similar to Sodium/hydrogen exchanger 3 (Na(+)/H(+) exchanger 3) (NHE-3) LOC150207 22q11.21 hypothetical gene LOC150207 POM121L4P 22 POM121 membrane glycoprotein-like 4 pseudogene (rat) DKFZp434N035 22q11.21 hypothetical protein DKFZp434N035 PIK4CA 22q11.21 phosphatidylinositol 4-kinase, catalytic, alpha polypeptide SERPIND1 22q11.21 serine (or cysteine) proteinase inhibitor, clade D (heparin cofactor), member 1 SNAP29 22q11.21 synaptosomal-associated protein, 29kDa CRKL 22q11.21 v-crk sarcoma virus CT10 oncogene homolog (avian)-like FLJ30473 22q11.21-q11.22 hypothetical protein FLJ30473 LZTR1 22q11.1-q11.2 leucine-zipper-like transcriptional regulator, 1 THAP7 22q11.2 THAP domain containing 7 FLJ39582 22q11.2 hypothetical protein FLJ39582 MGC16703 22q11.22 alpha tubulin-like P2RXL1 22q11.21 purinergic receptor P2X-like 1, orphan receptor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 - 3508 - 870 - 2002 12154095
    11 - 3493 - 865 - 2002 12154095
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   predominantly
    Digestivemouthtongue  highly
    Lymphoid/Immunethymusmedulla  highly
    Reproductivefemale systemovary  predominantly
    Respiratorylung   predominantly
    Skeletonaxial skeletonthoracic cageribs highly
    Visualeyeuveachoroid  
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialbarrier/liningretinal pigment epithelium (RPE)  
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Cardiovascularendothelial cell
    not specificdigestive
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text
  • placenta predominantly, eye
  • embryonic hair follicle, skin and nasal epithelium
  • PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • multiple epidermal growth factor-like domain
  • seven EGF-like domains
  • putative epidermal growth factor-like domains in its extracellular domain, along with a number of positively charged residues in its intracellular domain
  • HOMOLOGY
    intraspecies homolog to SCARF1 (highly)
    Homologene
    FAMILY scavenger receptor type F family
    CATEGORY receptor membrane
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • internalizing modified low density lipoproteins (LDL)
  • may be involved in intracellular signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to acetylated LDL and oxidized LDL
  • heterophilic interaction between SCARF1 and SCARF2 at their extracellular domains
  • SCARF1 and SCARF2, show weak cell-cell interaction by their extracellular domains (termed homophilic trans-interaction) but display strong heterophilic trans-interaction through the extracellular epidermal growth factor-like repeat domains
  • cell & other
    REGULATION
    activated by in the presence of oxidized LDL
    ASSOCIATED DISORDERS
    corresponding disease(s) VDEGS
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS