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FLASH GENE

Symbol

SCARF2

contributors: mct - updated : 26-10-2010

HGNC name	scavenger receptor class F, member 2
HGNC id	19869

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Corresponding disease	VDEGS Van Den Ende-Gupta Syndrome
Location	22q11.21      Physical location : 20.778.874 - 20.792.146
Synonym name	scavenger receptor type F
	scavenger receptor expressed by endothelial cells 2
Synonym symbol(s)	SRECII, HUMZD58C02, SREC2, SRECRP-1

DNA

TYPE	functioning gene
STRUCTURE	13.27 kb     11 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_153334 11 - 3508 NP_699165 - 870 - 2002 12154095 NM_182895 11 - 3493 NP_878315 - 865 - 2002 12154095

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       predominantly Digestive mouth tongue     highly Lymphoid/Immune thymus medulla     highly Reproductive female system ovary     predominantly Respiratory lung       predominantly Skeleton axial skeleton thoracic cage ribs   highly Visual eye uvea choroid

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier/lining retinal pigment epithelium (RPE)

cells

System Cell Pubmed Species Stage Rna symbol Cardiovascular endothelial cell not specific digestive

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal, pregnancy

Text	placenta predominantly, eye
	embryonic hair follicle, skin and nasal epithelium

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	multiple epidermal growth factor-like domain
	seven EGF-like domains
	putative epidermal growth factor-like domains in its extracellular domain, along with a number of positively charged residues in its intracellular domain

HOMOLOGY

intraspecies

homolog to SCARF1 (highly)

Homologene

FAMILY

scavenger receptor type F family

CATEGORY

receptor membrane

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	internalizing modified low density lipoproteins (LDL)
	may be involved in intracellular signaling

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	binding to acetylated LDL and oxidized LDL
	heterophilic interaction between SCARF1 and SCARF2 at their extracellular domains
	SCARF1 and SCARF2, show weak cell-cell interaction by their extracellular domains (termed homophilic trans-interaction) but display strong heterophilic trans-interaction through the extracellular epidermal growth factor-like repeat domains

cell & other

REGULATION

activated by

in the presence of oxidized LDL

ASSOCIATED DISORDERS

corresponding disease(s)

VDEGS

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS