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FLASH GENE

Symbol

SCARA3

contributors: mct/npt - updated : 31-07-2004

HGNC name	scavenger receptor class A, member 3
HGNC id	19000

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	8p21.1      Physical location : 27.491.576 - 27.534.286
Synonym name	cellular stress response protein 1
	anaphase promoting complex subunit 7
	macrophage scavenger receptor-like 1
Synonym symbol(s)	CSR, CSR1, MSLR1, APC7

DNA

TYPE	functioning gene
STRUCTURE	38.96 kb     6 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed variant 2 or CSR2 6 - 1711 52.3 466 - Zhu (2009) variant 1 or CSR1 6 - 3631 65 606 - Zhu (2009)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Visual eye       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a membrane-spanning
	an alpha-helix coiled-coil domain
	a collagen-like domain
	C terminus binds with cleavage and polyadenylation-specific factor 3 (CPSF3), an enzyme necessary for polyadenylation of RNA (Zhu 2009)

HOMOLOGY

Homologene

FAMILY

CATEGORY

tumor suppressor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,organelle,Golgi
text	primarily in the cytoplasm near the cell membrane (Zhu 2009)

basic FUNCTION	may be a potent tumor sup-pressor gene (Yu 2006)
	undergoes hypermethylation in over 30 p100 of prostate cancers (Zhu (2009)
	probably has a role beyond a cell stress-response gene (Zhu 2009)
	induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme (Zhu 2009)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein

binding to CPSF3 (induced redistribution of CPSF3 from the nucleus to the cytoplasm)(Zhu 2009)

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --low   in prostate cancer with associated with a high rate of prostate cancer metastasis(Yu 2006)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS