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FLASH GENE
Symbol SCAPER contributors: mct/npt - updated : 14-10-2009
HGNC name S phase cyclin A-associated protein in the ER
HGNC id 13081
Location 15q24.3      Physical location : 76.640.528 - 77.176.217
Synonym name zinc finger protein 291
Synonym symbol(s) MSTP063, KIAA1454, ZNF291, Zfp291, FLJ31533, FLJ31953, FLJ46212
DNA
TYPE functioning gene
STRUCTURE 535.68 kb     31 Exon(s)
motif repetitive sequence
text structure unstable [CCTG](n) repeat in the second intron (Laura 2007)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
31 - 4731 - 1400 - Tsang (2008)
- - 4874 - 1154 - Tsang (2008)
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Nervousbrain   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • U1-like zinc finger
  • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • zinc finger protein C2H2 type
  • CATEGORY RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    text localized to the endoplasmic reticulum (Tsang 2008)
    basic FUNCTION
  • RNA binding protein
  • by sequestering CCNA2/CDK2, is capable of directing the activity of this kinase complex away from the nucleus and regulating cyclin A/Cdk2 equilibrium in distinct subcellular compartments (Tsang 2008)
  • represents a novel CCNA2/CDK2 regulatory protein that transiently maintains this kinase in the cytoplasm (Tsang 2007)
  • could play a role in distinguishing S phase- from M phase-specific functions of CCNA2/CDK2 (Tsang 2007)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA binding
    small molecule metal binding,
  • Zn2+
  • protein
  • specifically interacts with CCNA2/CDK2 (Tsang 2007)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene attractive candidate for neuromuscular expansion related diseases mapping in this locus (Laura 2007)
    Marker
    Therapy target
    ANIMAL & CELL MODELS