Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Ensembl
	HGNC	UniGene	Nucleotide	OMIM	UCSC

Home Page

FLASH GENE

Symbol

SCAMP2

contributors: mct/npt/pgu - updated : 01-12-2009

HGNC name	secretory carrier membrane protein 2
HGNC id	10564

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	15q24.1      Physical location : 75.137.196 - 75.165.670

DNA

TYPE	functioning gene
STRUCTURE	28.47 kb     9 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005697 9 - 1313 NP_005688 - 329 - 2007 17713930

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine     highly Lymphoid/Immune spleen       highly Nervous nerve cranial nerve     highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective bone     highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	four putative transmembrane segments (4TM)
	a serie of motifs including a calcium binding domain, a leucine zipper and two zinc finger domains
	a basic/hydrophobic peptide segment (SCAMP2 E: CWYRPIYKAFR) implicated in the membrane fusion in calcium-dependent granule exocytosis

HOMOLOGY

Homologene

FAMILY

SCAMP family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,organelle,membrane
	intracellular,cytoplasm,organelle,Golgi
	intracellular,cytoplasm,organelle,endosome
text	integral membrane protein that reside in multiple secretory and endocytic organelles, bind to SLC9A5 and co-localize predominantly in the recycling endosomes

basic FUNCTION	involved in cell surface recycling
	coupling ARF6-stimulated PLD activity to exocytosis and links this process to formation of fusion pores
	having an essential function in granule exocytosis through actions mediated by its E peptide-containing domain
	plays an important role in the regulation of the subcellular distribution of SLC6A4
	functioning in late steps of membrane fusion in calcium-dependent granule exocytosis
	tetraspanning integral membrane proteins that reside in multiple secretory and endocytic organelles
	regulates SLC9A5 transit through recycling endosomes and promotes its surface targeting in an Arf6-dependent manner
	plays a role in the functional regulation of SLC6A3
	involved in the functional regulation of SLC6A3 and potential role for SCAMP2 in modulating the homeostasis of monoamines in the synapse
	role for SCAMP2 in coordinating the subcellular distribution of SLC6A3, suggesting that SCAMP2 may be involved in transporter cell surface expression

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component	widely distributed constituent of post-Golgi membranes
	complexing with SLC6A4 (SCAMP2 plays an important role in the regulation of the subcellular distribution of SLC6A4)

INTERACTION

DNA

RNA

small molecule

protein	interacts with ARF6 and phospholipase D1
	associated with SLC9A7 (participate in the shuttling of SLC9A7 between recycling vesicles and the trans-Golgi network)
	SLC6A4 interacting protein (physical interaction between SCAMP2 and the N-terminal domain of SLC6A4)
	interaction with PIB5PA within the membrane interface regulates fusion pore formation during exocytosis
	bind to SLC9A5 and co-localize predominantly in the recycling endosomes
	functional interaction between SLC6A4 and the Secretory Carrier Membrane Protein 2 (SCAMP2)

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS