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FLASH GENE
Symbol SCAMP2 contributors: mct/npt/pgu - updated : 01-12-2009
HGNC name secretory carrier membrane protein 2
HGNC id 10564
Location 15q24.1      Physical location : 75.137.196 - 75.165.670
DNA
TYPE functioning gene
STRUCTURE 28.47 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
9 - 1313 - 329 - 2007 17713930
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine  highly
Lymphoid/Immunespleen   highly
Nervousnervecranial nerve  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • four putative transmembrane segments (4TM)
  • a serie of motifs including a calcium binding domain, a leucine zipper and two zinc finger domains
  • a basic/hydrophobic peptide segment (SCAMP2 E: CWYRPIYKAFR) implicated in the membrane fusion in calcium-dependent granule exocytosis
  • HOMOLOGY
    Homologene
    FAMILY
  • SCAMP family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    text integral membrane protein that reside in multiple secretory and endocytic organelles, bind to SLC9A5 and co-localize predominantly in the recycling endosomes
    basic FUNCTION
  • involved in cell surface recycling
  • coupling ARF6-stimulated PLD activity to exocytosis and links this process to formation of fusion pores
  • having an essential function in granule exocytosis through actions mediated by its E peptide-containing domain
  • plays an important role in the regulation of the subcellular distribution of SLC6A4
  • functioning in late steps of membrane fusion in calcium-dependent granule exocytosis
  • tetraspanning integral membrane proteins that reside in multiple secretory and endocytic organelles
  • regulates SLC9A5 transit through recycling endosomes and promotes its surface targeting in an Arf6-dependent manner
  • plays a role in the functional regulation of SLC6A3
  • involved in the functional regulation of SLC6A3 and potential role for SCAMP2 in modulating the homeostasis of monoamines in the synapse
  • role for SCAMP2 in coordinating the subcellular distribution of SLC6A3, suggesting that SCAMP2 may be involved in transporter cell surface expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • widely distributed constituent of post-Golgi membranes
  • complexing with SLC6A4 (SCAMP2 plays an important role in the regulation of the subcellular distribution of SLC6A4)
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with ARF6 and phospholipase D1
  • associated with SLC9A7 (participate in the shuttling of SLC9A7 between recycling vesicles and the trans-Golgi network)
  • SLC6A4 interacting protein (physical interaction between SCAMP2 and the N-terminal domain of SLC6A4)
  • interaction with PIB5PA within the membrane interface regulates fusion pore formation during exocytosis
  • bind to SLC9A5 and co-localize predominantly in the recycling endosomes
  • functional interaction between SLC6A4 and the Secretory Carrier Membrane Protein 2 (SCAMP2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS